News and Views
Nature Cell Biology 6, 12 - 14 (2004)
doi:10.1038/ncb0104-12
Formin' adherens junctions
Sally Zigmond1
-
Sally Zigmond is in the Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA.
e-mail: szigmond@sas.upenn.edu
Abstract
Epithelial cells are joined by adherens junctions, which consist of homotypic interactions between extracellular domains of E-cadherins. Inside the cell, the tails of E-cadherins bind actin cables through 
-catenin and 
-catenin. Formin1 is critically important for the formation of actin cables; it binds directly to -catenin and can even bypass the need for -catenin when targeted to -catenin.
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