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Editorial

Molecular biology, cell biology and NCB p763

doi:10.1038/ncb0903-763


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Correspondence

Deletion of Mia1/Alp7 activates Mad2-dependent spindle assembly checkpoint in fission yeast pp764 - 766

Masamitsu Sato, Nirada Koonrugsa, Takashi Toda, Leah Vardy, Sylvie Tournier & Jonathan B. A. Millar

doi:10.1038/ncb0903-764


Reply: Deletion of Mia1/Alp7 activates Mad2-dependent spindle assembly checkpoint in fission yeast p766

Snezhana Oliferenko & Mohan K. Balasubramanian

doi:10.1038/ncb0903-766


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Book Review

Managing microarrays p767

Paul S. Meltzer reviews DNA Microarrays: A molecular cloning manual by David Bowtell & Joseph Sambrook

doi:10.1038/ncb0903-767


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News and Views

Unfolding the toxicity of cholesterol pp769 - 770

Kezhong Zhang & Randal J. Kaufman

doi:10.1038/ncb0903-769

A critical attribute of advanced atherosclerosis is the accumulation of free cholesterol in macrophages, triggering cell death. Now, a study reveals that the key events that result in cholesterol-induced macrophage death are the depletion of endoplasmic reticulum calcium stores by free cholesterol and subsequent activation of the unfolded protein response.


Small-interfering RNAs in the radar of the interferon system pp771 - 772

Eric G. Moss & John M. Taylor

doi:10.1038/ncb0903-771

The expanding use of small RNA technology to silence specific genes shows no signs of slowing down. However, the discovery that it can induce components of the interferon system in animal cells should make us pause to consider potential non-specific effects of this technique.


RNA interference: RISCing chromatin silence p773

Sowmya Swaminathan

doi:10.1038/ncb0903-773a


Deconstructing cytokinesis pp773 - 776

Amy Shaub Maddox & Karen Oegema

doi:10.1038/ncb0903-773b

In animal cells, cytokinesis is initiated by assembly and ingression of a cleavage furrow, the position of which is determined by signals from the anaphase spindle. Recent work highlights two specialized microtubule populations that may stimulate furrow assembly: inter-zonal microtubule bundles, and astral microtubules that are stabilized by proximity to chromosomes.


Phagosomes, fatty acids and tuberculosis pp776 - 778

David G. Russell

doi:10.1038/ncb0903-776

An acknowledged key to the success of Mycobacterium tuberculosis as a pathogen is its ability to prevent the fusion of a phagosome containing the internalized bacterium with the host cell's lysosomal system. Recent work examines the modulation of phagosome maturation by addition of exogenous fatty acids and discusses the implications that this could have for anti-tuberculosis therapy or prophylaxis.


Tip of the POP2 p778

Donald Mcdonald

doi:10.1038/ncb0903-778


Cell of the month: Neural progenitor cells expressing tyrosine hydrolase p779

Yu-Tzu Tai

doi:10.1038/ncb0903-779


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Articles

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages pp781 - 792

Bo Feng, Pin Mei Yao, Yankun Li, Cecilia M. Devlin, Dajun Zhang, Heather P. Harding, Michele Sweeney, James X. Rong, George Kuriakose, Edward A. Fisher, Andrew R. Marks, David Ron & Ira Tabas

doi:10.1038/ncb1035



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Letters

Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells pp803 - 811

Michael Beil, Alexandre Micoulet, Götz von Wichert, Stephan Paschke, Paul Walther, M. Bishr Omary, Paul P. Van Veldhoven, Ulrike Gern, Elke Wolff-Hieber, Juliane Eggermann, Johannes Waltenberger, Guido Adler, Joachim Spatz & Thomas Seufferlein

doi:10.1038/ncb1037


Activation of the interferon system by short-interfering RNAs pp834 - 839

Carol A. Sledz, Michelle Holko, Michael J. de Veer, Robert H. Silverman & Bryan R.G. Williams

doi:10.1038/ncb1038


CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth pp819 - 826

Takashi Nishimura, Yuko Fukata, Katsuhiro Kato, Tomoya Yamaguchi, Yoshiharu Matsuura, Hiroyuki Kamiguchi & Kozo Kaibuchi

doi:10.1038/ncb1039



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