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Volume 5 Issue 9, September 2003

A scanning electron micrograph of the keratin filament network of human pancreatic cells after sphingosylphosphorylcholine treatment, showing a marked perinuclear reorganisation of keratin filaments accompanied by rarefication of the filaments in the cytoplasm. Cover design: James McQuat

Volume 5 Issue 9

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Editorial

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Correspondence

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Book Review

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News & Views

  • A critical attribute of advanced atherosclerosis is the accumulation of free cholesterol in macrophages, triggering cell death. Now, a study reveals that the key events that result in cholesterol-induced macrophage death are the depletion of endoplasmic reticulum calcium stores by free cholesterol and subsequent activation of the unfolded protein response.

    • Kezhong Zhang
    • Randal J. Kaufman
    News & Views

  • The expanding use of small RNA technology to silence specific genes shows no signs of slowing down. However, the discovery that it can induce components of the interferon system in animal cells should make us pause to consider potential non-specific effects of this technique.

    • Eric G. Moss
    • John M. Taylor
    News & Views

  • In animal cells, cytokinesis is initiated by assembly and ingression of a cleavage furrow, the position of which is determined by signals from the anaphase spindle. Recent work highlights two specialized microtubule populations that may stimulate furrow assembly: inter-zonal microtubule bundles, and astral microtubules that are stabilized by proximity to chromosomes.

    • Amy Shaub Maddox
    • Karen Oegema
    News & Views

  • An acknowledged key to the success of Mycobacterium tuberculosis as a pathogen is its ability to prevent the fusion of a phagosome containing the internalized bacterium with the host cell's lysosomal system. Recent work examines the modulation of phagosome maturation by addition of exogenous fatty acids and discusses the implications that this could have for anti-tuberculosis therapy or prophylaxis.

    • David G. Russell
    News & Views
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Letter

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