Molecular biology, cell biology and NCB - p763

doi:10.1038/ncb0903-763

Full Text - Molecular biology, cell biology and NCB | PDF (59 KB) - Molecular biology, cell biology and NCB

Deletion of Mia1/Alp7 activates Mad2-dependent spindle assembly checkpoint in fission yeast - pp764 - 766

Masamitsu Sato, Nirada Koonrugsa, Takashi Toda, Leah Vardy, Sylvie Tournier & Jonathan B. A. Millar

doi:10.1038/ncb0903-764

Full Text - Deletion of Mia1/Alp7 activates Mad2-dependent spindle assembly checkpoint in fission yeast | PDF (287 KB) - Deletion of Mia1/Alp7 activates Mad2-dependent spindle assembly checkpoint in fission yeast

Reply: Deletion of Mia1/Alp7 activates Mad2-dependent spindle assembly checkpoint in fission yeast - p766

Snezhana Oliferenko & Mohan K. Balasubramanian

doi:10.1038/ncb0903-766

Full Text - Reply: Deletion of Mia1/Alp7 activates Mad2-dependent spindle assembly checkpoint in fission yeast | PDF (77 KB) - Reply: Deletion of Mia1/Alp7 activates Mad2-dependent spindle assembly checkpoint in fission yeast

Managing microarrays - p767

Paul S. Meltzer reviews DNA Microarrays: A molecular cloning manual by David Bowtell & Joseph Sambrook

doi:10.1038/ncb0903-767

Full Text - Managing microarrays | PDF (86 KB) - Managing microarrays

Unfolding the toxicity of cholesterol - pp769 - 770

Kezhong Zhang & Randal J. Kaufman

doi:10.1038/ncb0903-769

A critical attribute of advanced atherosclerosis is the accumulation of free cholesterol in macrophages, triggering cell death. Now, a study reveals that the key events that result in cholesterol-induced macrophage death are the depletion of endoplasmic reticulum calcium stores by free cholesterol and subsequent activation of the unfolded protein response.

Full Text - Unfolding the toxicity of cholesterol | PDF (110 KB) - Unfolding the toxicity of cholesterol

Small-interfering RNAs in the radar of the interferon system - pp771 - 772

Eric G. Moss & John M. Taylor

doi:10.1038/ncb0903-771

The expanding use of small RNA technology to silence specific genes shows no signs of slowing down. However, the discovery that it can induce components of the interferon system in animal cells should make us pause to consider potential non-specific effects of this technique.

Full Text - Small-interfering RNAs in the radar of the interferon system | PDF (106 KB) - Small-interfering RNAs in the radar of the interferon system

RNA interference: RISCing chromatin silence - p773

Sowmya Swaminathan

doi:10.1038/ncb0903-773a

Full Text - RNA interference: RISCing chromatin silence | PDF (95 KB) - RNA interference: RISCing chromatin silence

Deconstructing cytokinesis - pp773 - 776

Amy Shaub Maddox & Karen Oegema

doi:10.1038/ncb0903-773b

In animal cells, cytokinesis is initiated by assembly and ingression of a cleavage furrow, the position of which is determined by signals from the anaphase spindle. Recent work highlights two specialized microtubule populations that may stimulate furrow assembly: inter-zonal microtubule bundles, and astral microtubules that are stabilized by proximity to chromosomes.

Full Text - Deconstructing cytokinesis | PDF (277 KB) - Deconstructing cytokinesis

Phagosomes, fatty acids and tuberculosis - pp776 - 778

David G. Russell

doi:10.1038/ncb0903-776

An acknowledged key to the success of Mycobacterium tuberculosis as a pathogen is its ability to prevent the fusion of a phagosome containing the internalized bacterium with the host cell's lysosomal system. Recent work examines the modulation of phagosome maturation by addition of exogenous fatty acids and discusses the implications that this could have for anti-tuberculosis therapy or prophylaxis.

Full Text - Phagosomes, fatty acids and tuberculosis | PDF (151 KB) - Phagosomes, fatty acids and tuberculosis

Tip of the POP2 - p778

Donald Mcdonald

doi:10.1038/ncb0903-778

Full Text - Tip of the POP2 | PDF (109 KB) - Tip of the POP2

Cell of the month: Neural progenitor cells expressing tyrosine hydrolase - p779

Yu-Tzu Tai

doi:10.1038/ncb0903-779

Full Text - Cell of the month: Neural progenitor cells expressing tyrosine hydrolase | PDF (555 KB) - Cell of the month: Neural progenitor cells expressing tyrosine hydrolase

Targeted movement of cell end factors in fission yeast - pp812 - 818

Heidi Browning, David D. Hackney & Paul Nurse

doi:10.1038/ncb1034

First Paragraph - Targeted movement of cell end factors in fission yeast | Full Text - Targeted movement of cell end factors in fission yeast | PDF (428 KB) - Targeted movement of cell end factors in fission yeast | Supplementary information

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages - pp781 - 792

Bo Feng, Pin Mei Yao, Yankun Li, Cecilia M. Devlin, Dajun Zhang, Heather P. Harding, Michele Sweeney, James X. Rong, George Kuriakose, Edward A. Fisher, Andrew R. Marks, David Ron & Ira Tabas

doi:10.1038/ncb1035

Abstract - The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages | Full Text - The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages | PDF (1,706 KB) - The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria - pp793 - 802

Elsa Anes, Mark Philipp Kühnel, Evelyne Bos, Jose Moniz-Pereira, Anja Habermann & Gareth Griffiths

doi:10.1038/ncb1036

Abstract - Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria | Full Text - Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria | PDF (425 KB) - Selected lipids activate phagosome actin assembly and maturation resulting in killing of pathogenic mycobacteria | Supplementary information

Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells - pp803 - 811

Michael Beil, Alexandre Micoulet, Götz von Wichert, Stephan Paschke, Paul Walther, M. Bishr Omary, Paul P. Van Veldhoven, Ulrike Gern, Elke Wolff-Hieber, Juliane Eggermann, Johannes Waltenberger, Guido Adler, Joachim Spatz & Thomas Seufferlein

doi:10.1038/ncb1037

First Paragraph - Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells | Full Text - Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells | PDF (6,433 KB) - Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells | Supplementary information

Activation of the interferon system by short-interfering RNAs - pp834 - 839

Carol A. Sledz, Michelle Holko, Michael J. de Veer, Robert H. Silverman & Bryan R.G. Williams

doi:10.1038/ncb1038

First Paragraph - Activation of the interferon system by short-interfering RNAs | Full Text - Activation of the interferon system by short-interfering RNAs | PDF (232 KB) - Activation of the interferon system by short-interfering RNAs | Supplementary information

CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth - pp819 - 826

Takashi Nishimura, Yuko Fukata, Katsuhiro Kato, Tomoya Yamaguchi, Yoshiharu Matsuura, Hiroyuki Kamiguchi & Kozo Kaibuchi

doi:10.1038/ncb1039

First Paragraph - CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth | Full Text - CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth | PDF (1,673 KB) - CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth | Supplementary information

Wingless promotes cell survival but constrains growth during Drosophila wing development - pp827 - 833

Laura A. Johnston & Angela L. Sanders

doi:10.1038/ncb1041

First Paragraph - Wingless promotes cell survival but constrains growth during : Drosophila: wing development | Full Text - Wingless promotes cell survival but constrains growth during Drosophila wing development | PDF (2,343 KB) - Wingless promotes cell survival but constrains growth during Drosophila wing development | Supplementary information

Addendum: Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells - p839

doi:10.1038/ncb1042

Full Text - Addendum: Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells | PDF (34 KB) - Addendum: Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells

Erratum: Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts - p839

doi:10.1038/ncb1043

Full Text - Erratum: Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts | PDF (30 KB) - Erratum: Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts