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Letter
Nature Cell Biology 5, 803–811 (1 September 2003) | doi:10.1038/ncb1037
Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells
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Abstract
Sphingosylphosphorylcholine (SPC) is a naturally occurring bioactive lipid that is present in high density lipoproteins (HDL) particles and found at increased levels in blood and malignant ascites of patients with ovarian cancer. Here, we show that incubation of human epithelial tumour cells with SPC induces a perinuclear reorganization of intact keratin 8–18 filaments.
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