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Nature Cell Biology 5, 776 - 778 (2003)
doi:10.1038/ncb0903-776
Phagosomes, fatty acids and tuberculosis
David G. Russell1
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David G. Russell is in the Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
e-mail: dgr8@cornell.edu
Abstract
An acknowledged key to the success of Mycobacterium tuberculosis as a pathogen is its ability to prevent the fusion of a phagosome containing the internalized bacterium with the host cell's lysosomal system. Recent work examines the modulation of phagosome maturation by addition of exogenous fatty acids and discusses the implications that this could have for anti-tuberculosis therapy or prophylaxis.
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