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Nature Cell Biology 5, 769 - 770 (2003)
doi:10.1038/ncb0903-769

Unfolding the toxicity of cholesterol

Kezhong Zhang1 & Randal J. Kaufman2

  1. Kezhong Zhang is at the Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
  2. Randal J. Kaufman is at the Department of Biological Chemistry and the Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
    e-mail: kaufmanr@umich.edu

A critical attribute of advanced atherosclerosis is the accumulation of free cholesterol in macrophages, triggering cell death. Now, a study reveals that the key events that result in cholesterol-induced macrophage death are the depletion of endoplasmic reticulum calcium stores by free cholesterol and subsequent activation of the unfolded protein response.

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