Table of contents


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Editorial

Making impact p681

doi:10.1038/ncb0803-681


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Book Review

Putting DNA in its place p683

Wallace F. Marshall reviews Chromosomes: Organization and Function by Adrian T. Sumner

doi:10.1038/ncb0803-683


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Perspective

Why do worms need cholesterol? pp684 - 688

Teymuras V. Kurzchalia & Samuel Ward

doi:10.1038/ncb0803-684


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News and Views

Cdk5 is a dynamo at the synapse pp689 - 690

Benjamin Adam Samuels & Li-Huei Tsai

doi:10.1038/ncb0803-689

Synaptic vesicle recycling is a highly regulated process that involves the coordinated function of several different presynaptic proteins including the dephosphins, whose dephosphorylation is important for triggering endocytosis. Subsequent rounds of endocytosis then depend on rephosphorylation of dephosphins. Recent work establishes Cdk5 as a dephosphin kinase whose function is necessary for synaptic vesicle endocytosis.


New dimensions in cell migration pp690 - 692

Donna J. Webb & Alan F. Horwitz

doi:10.1038/ncb0803-690

Cell migration research is taking some intriguing new turns. Emerging studies are revealing marked differences in the way that cells migrate in two versus three dimensions, plasticity in their migration mechanisms and diversity in the contribution of different Rho family GTPases that drive various modes of migration.


Getting a GPR on spindle asymmetry p692

Sowmya Swaminathan

doi:10.1038/ncb0803-692


Actin puts on the squeeze pp693 - 694

Dorothy A. Schafer

doi:10.1038/ncb0803-693

Compensatory endocytosis retrieves membrane and proteins that are deposited at the plasma membrane during exocytosis. A new study reveals that actin filaments assemble into structures that compress membrane-bound endocytic compartments formed after exocytosis. This suggests that compressive forces generated by actin polymerization might remodel membranes during secretory and endocytic traffic.


Talin forges the links between integrins and actin pp694 - 697

David A. Calderwood & Mark H. Ginsberg

doi:10.1038/ncb0803-694

The physical link between integrin adhesion receptors and the actin cytoskeleton mediates bidirectional transmission of force and biochemical signals across the plasma membrane. This link is essential for the development and function of multicellular animals. Recent work reveals that the integrin-associated actin-binding protein talin provides the initial connections between integrins and the cytoskeleton, establishing a pivotal role for this connection in bi-directional integrin signalling.


Curling with kinesin p696

Jack Horne

doi:10.1038/ncb0803-696


The sirens' call pp697 - 699

Valerie A. Fadok

doi:10.1038/ncb0803-697

Cells dying by apoptosis acquire 'eat me' signals and lose 'don't eat me' signals to trigger recognition and uptake by phagocytes. How do these sirens of death call the macrophages into a site of massive cell death during tissue remodelling? Release of soluble chemotactic factors, including lysophosphatidylcholine, seems to be the sirens' call.


Cell of the month: A plant hair cell on a leaf primordium of Arabidopsis thaliana p699

John Runions

doi:10.1038/ncb0803-699


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Articles

Cdk5 is essential for synaptic vesicle endocytosis pp701 - 710

Timothy C. Tan, Valentina A. Valova, Chandra S. Malladi, Mark E. Graham, Leise A. Berven, Orla J. Jupp, Gurdip Hansra, Sonya J. McClure, Boris Sarcevic, Ross A. Boadle, Martin R. Larsen, Michael A. Cousin & Phillip J. Robinson

doi:10.1038/ncb1020

See also: News and Views by Samuels & Tsai



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Letters

Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells pp720 - 726

Guy Tran Van Nhieu, Caroline Clair, Roberto Bruzzone, Marc Mesnil, Philippe Sansonetti & Laurent Combettes

doi:10.1038/ncb1021


Cdc42-dependent actin polymerization during compensatory endocytosis in Xenopus eggs pp727 - 732

Anna Marie Sokac, Carl Co, Jack Taunton & William Bement

doi:10.1038/ncb1025

See also: News and Views by Schafer


Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis pp733 - 740

Mauricio J. Reginato, Kenna R. Mills, Jessica K. Paulus, Danielle K. Lynch, Dennis C. Sgroi, Jayanta Debnath, Senthil K. Muthuswamy & Joan S. Brugge

doi:10.1038/ncb1026


Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts pp741 - 747

Simona Parrinello, Enrique Samper, Ana Krtolica, Joshua Goldstein, Simon Melov & Judith Campisi

doi:10.1038/ncb1024



A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter pp754 - 761

Vanessa Brès, Rosemary E. Kiernan, Laetitia K. Linares, Christine Chable-Bessia, Olga Plechakova, Céline Tréand, Stephane Emiliani, Jean-Marie Peloponese, Kuan-Teh Jeang, Olivier Coux, Martin Scheffner & Monsef Benkirane

doi:10.1038/ncb1023


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