Making impact - p681

doi:10.1038/ncb0803-681

Full Text - Making impact | PDF (59 KB) - Making impact

Putting DNA in its place - p683

Wallace F. Marshall reviews Chromosomes: Organization and Function by Adrian T. Sumner

doi:10.1038/ncb0803-683

Full Text - Putting DNA in its place | PDF (88 KB) - Putting DNA in its place

Why do worms need cholesterol? - pp684 - 688

Teymuras V. Kurzchalia & Samuel Ward

doi:10.1038/ncb0803-684

Abstract - | Full Text - Why do worms need cholesterol? | PDF (121 KB) - Why do worms need cholesterol?

Cdk5 is a dynamo at the synapse - pp689 - 690

Benjamin Adam Samuels & Li-Huei Tsai

doi:10.1038/ncb0803-689

Synaptic vesicle recycling is a highly regulated process that involves the coordinated function of several different presynaptic proteins including the dephosphins, whose dephosphorylation is important for triggering endocytosis. Subsequent rounds of endocytosis then depend on rephosphorylation of dephosphins. Recent work establishes Cdk5 as a dephosphin kinase whose function is necessary for synaptic vesicle endocytosis.

Full Text - Cdk5 is a dynamo at the synapse | PDF (100 KB) - Cdk5 is a dynamo at the synapse

New dimensions in cell migration - pp690 - 692

Donna J. Webb & Alan F. Horwitz

doi:10.1038/ncb0803-690

Cell migration research is taking some intriguing new turns. Emerging studies are revealing marked differences in the way that cells migrate in two versus three dimensions, plasticity in their migration mechanisms and diversity in the contribution of different Rho family GTPases that drive various modes of migration.

Full Text - New dimensions in cell migration | PDF (225 KB) - New dimensions in cell migration

Getting a GPR on spindle asymmetry - p692

Sowmya Swaminathan

doi:10.1038/ncb0803-692

Full Text - Getting a GPR on spindle asymmetry | PDF (155 KB) - Getting a GPR on spindle asymmetry

Actin puts on the squeeze - pp693 - 694

Dorothy A. Schafer

doi:10.1038/ncb0803-693

Compensatory endocytosis retrieves membrane and proteins that are deposited at the plasma membrane during exocytosis. A new study reveals that actin filaments assemble into structures that compress membrane-bound endocytic compartments formed after exocytosis. This suggests that compressive forces generated by actin polymerization might remodel membranes during secretory and endocytic traffic.

Full Text - Actin puts on the squeeze | PDF (97 KB) - Actin puts on the squeeze

Talin forges the links between integrins and actin - pp694 - 697

David A. Calderwood & Mark H. Ginsberg

doi:10.1038/ncb0803-694

The physical link between integrin adhesion receptors and the actin cytoskeleton mediates bidirectional transmission of force and biochemical signals across the plasma membrane. This link is essential for the development and function of multicellular animals. Recent work reveals that the integrin-associated actin-binding protein talin provides the initial connections between integrins and the cytoskeleton, establishing a pivotal role for this connection in bi-directional integrin signalling.

Full Text - Talin forges the links between integrins and actin | PDF (307 KB) - Talin forges the links between integrins and actin

Curling with kinesin - p696

Jack Horne

doi:10.1038/ncb0803-696

Full Text - Curling with kinesin | PDF (153 KB) - Curling with kinesin

The sirens' call - pp697 - 699

Valerie A. Fadok

doi:10.1038/ncb0803-697

Cells dying by apoptosis acquire 'eat me' signals and lose 'don't eat me' signals to trigger recognition and uptake by phagocytes. How do these sirens of death call the macrophages into a site of massive cell death during tissue remodelling? Release of soluble chemotactic factors, including lysophosphatidylcholine, seems to be the sirens' call.

Full Text - The sirens' call | PDF (461 KB) - The sirens' call

Cell of the month: A plant hair cell on a leaf primordium of Arabidopsis thaliana - p699

John Runions

doi:10.1038/ncb0803-699

Full Text - Cell of the month: A plant hair cell on a leaf primordium of Arabidopsis thaliana | PDF (247 KB) - Cell of the month: A plant hair cell on a leaf primordium of Arabidopsis thaliana

Cdk5 is essential for synaptic vesicle endocytosis - pp701 - 710

Timothy C. Tan, Valentina A. Valova, Chandra S. Malladi, Mark E. Graham, Leise A. Berven, Orla J. Jupp, Gurdip Hansra, Sonya J. McClure, Boris Sarcevic, Ross A. Boadle, Martin R. Larsen, Michael A. Cousin & Phillip J. Robinson

doi:10.1038/ncb1020

Abstract - | Full Text - Cdk5 is essential for synaptic vesicle endocytosis | PDF (2,674 KB) - Cdk5 is essential for synaptic vesicle endocytosis | Supplementary information

See also: News and Views by Samuels & Tsai

Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis - pp711 - 719

Erik Sahai & Christopher J. Marshall

doi:10.1038/ncb1019

First Paragraph - | Full Text - Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis | PDF (3,701 KB) - Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis | Supplementary information

See also: News and Views by Webb & Horwitz

Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells - pp720 - 726

Guy Tran Van Nhieu, Caroline Clair, Roberto Bruzzone, Marc Mesnil, Philippe Sansonetti & Laurent Combettes

doi:10.1038/ncb1021

First Paragraph - | Full Text - Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells | PDF (785 KB) - Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells | Supplementary information

Cdc42-dependent actin polymerization during compensatory endocytosis in Xenopus eggs - pp727 - 732

Anna Marie Sokac, Carl Co, Jack Taunton & William Bement

doi:10.1038/ncb1025

First Paragraph - | Full Text - Cdc42-dependent actin polymerization during compensatory endocytosis in Xenopus eggs | PDF (1,030 KB) - Cdc42-dependent actin polymerization during compensatory endocytosis in Xenopus eggs | Supplementary information

See also: News and Views by Schafer

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis - pp733 - 740

Mauricio J. Reginato, Kenna R. Mills, Jessica K. Paulus, Danielle K. Lynch, Dennis C. Sgroi, Jayanta Debnath, Senthil K. Muthuswamy & Joan S. Brugge

doi:10.1038/ncb1026

First Paragraph - | Full Text - Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis | PDF (1,272 KB) - Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis | Supplementary information

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts - pp741 - 747

Simona Parrinello, Enrique Samper, Ana Krtolica, Joshua Goldstein, Simon Melov & Judith Campisi

doi:10.1038/ncb1024

First Paragraph - | Full Text - Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts | PDF (740 KB) - Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts | Supplementary information

Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint - pp748 - 753

Eunah Chung & Rey-Huei Chen

doi:10.1038/ncb1022

First Paragraph - | Full Text - Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint | PDF (375 KB) - Phosphorylation of Cdc20 is required for its inhibition by the spindle checkpoint | Supplementary information

A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter - pp754 - 761

Vanessa Brès, Rosemary E. Kiernan, Laetitia K. Linares, Christine Chable-Bessia, Olga Plechakova, Céline Tréand, Stephane Emiliani, Jean-Marie Peloponese, Kuan-Teh Jeang, Olivier Coux, Martin Scheffner & Monsef Benkirane

doi:10.1038/ncb1023

First Paragraph - | Full Text - A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter | PDF (437 KB) - A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter | Supplementary information