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Letter
Nature Cell Biology 5, 733–740 (1 August 2003) | doi:10.1038/ncb1026
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis
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Abstract
Epithelial cells must adhere to the extracellular matrix (ECM) for survival, as detachment from matrix triggers apoptosis or anoikis. Integrins are major mediators of adhesion between cells and ECM proteins, and transduce signals required for cell survival.
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