1. Benjamin Adam Samuels is in the Department of Pathology, Harvard Medical School and the Program in Neuroscience, Harvard University, 200 Longwood Avenue, Boston MA 02115, USA.
   e-mail: benjamin_samuels@student.hms.harvard.edu
2. Li-Huei Tsai is in the Department of Pathology, Harvard Medical School, the Program in Neuroscience, Harvard University and Howard Hughes Medical Institute, 200 Longwood Avenue, Boston MA 02115, USA.
   e-mail: li-huei_tsai@hms.harvard.edu

Abstract

Synaptic vesicle recycling is a highly regulated process that involves the coordinated function of several different presynaptic proteins including the dephosphins, whose dephosphorylation is important for triggering endocytosis. Subsequent rounds of endocytosis then depend on rephosphorylation of dephosphins. Recent work establishes Cdk5 as a dephosphin kinase whose function is necessary for synaptic vesicle endocytosis.

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