Editorial procedures reviewed - pp583 - 584

doi:10.1038/ncb0703-583

Full Text - Editorial procedures reviewed | PDF (183 KB) - Editorial procedures reviewed

Cell Biology online: Ergito - p585

Eric Karsenti reviews

doi:10.1038/ncb0703-585

Full Text - Cell Biology online: Ergito | PDF (45 KB) - Cell Biology online: Ergito

The yin and yang of E2F-1: balancing life and death - pp587 - 589

Nicholas B. La Thangue

doi:10.1038/ncb0703-587

E2F transcription factors coordinate the timely expression of genes during early cell-cycle progression. In addition, the E2F-1 subunit can induce apoptosis in response to DNA damage. New results reveal an unexpected function for E2F-1 in suppressing apoptosis, which may be important in explaining the contribution of E2F-1 to tumorigenesis.

Full Text - The yin and yang of E2F-1: balancing life and death | PDF (105 KB) - The yin and yang of E2F-1: balancing life and death

Movin' on through with Cdc2 - pp589 - 590

Rudy Juliano

doi:10.1038/ncb0703-589

Proteins that control the cell cycle would seem to have little to do with cell migration. However, a recent report indicates that Cdc2, a key cyclin-dependent kinase, can also enhance cell migration. Levels of Cdc2 are upregulated in cells that express high levels of the _v3 integrin, a protein that has long been implicated in enhanced migration and invasion of tumour cells.

Full Text - Movin' on through with Cdc2 | PDF (117 KB) - Movin' on through with Cdc2

Recasting meiotic cohesion - p591

Donald McDonald

doi:10.1038/ncb0703-591a

Full Text - Recasting meiotic cohesion | PDF (110 KB) - Recasting meiotic cohesion

Neuronal polarization: building fences for molecular segregation - pp591 - 594

Carlos G. Dotti & Mu-ming Poo

doi:10.1038/ncb0703-591b

Neurons exhibit distinct compositions in the axonal and dendrite plasma membrane, but it remains ambiguous whether or not a diffusion barrier is needed to keep the different components separated. Now, Nakada et al. utilize state of the art microscopy to follow the dynamics of single lipids or proteins inserted in different areas along the axonal and dendritic surface of neurons at different developmental stages. The results obtained shed new light on the mechanism underlying polarized segregation of membrane components in neurons.

Full Text - Neuronal polarization: building fences for molecular segregation | PDF (166 KB) - Neuronal polarization: building fences for molecular segregation

A game of HIV and mouse - p594

Bernd Pulverer

doi:10.1038/ncb0703-594

Full Text - A game of HIV and mouse | PDF (73 KB) - A game of HIV and mouse

Claudin complexities at the apical junctional complex - pp595 - 597

Ulrich Tepass

doi:10.1038/ncb0703-595

Chordate claudins are core components of tight junctions. By contrast, VAB-9, a nematode four-pass transmembrane protein related to claudins, localizes to adherens junctions and contributes to cell adhesion and actin–plasma membrane association.

Full Text - Claudin complexities at the apical junctional complex | PDF (90 KB) - Claudin complexities at the apical junctional complex

Cell of the month: The vascular smooth muscle cell cytoskeleton - p598

Mario Gimona

doi:10.1038/ncb0703-598

Full Text - Cell of the month: The vascular smooth muscle cell cytoskeleton | PDF (2,394 KB) - Cell of the month: The vascular smooth muscle cell cytoskeleton

Conserved microtubule–actin interactions in cell movement and morphogenesis - pp599 - 609

Olga C. Rodriguez, Andrew W. Schaefer, Craig A. Mandato, Paul Forscher, William M. Bement & Clare M. Waterman-Storer

doi:10.1038/ncb0703-599

Abstract - Conserved microtubule-actin interactions in cell movement and morphogenesis | Full Text - Conserved microtubule–actin interactions in cell movement and morphogenesis | PDF (1,983 KB) - Conserved microtubule–actin interactions in cell movement and morphogenesis

Retraction - p680

doi:10.1038/ncb0703-680a

Full Text - Retraction | PDF (265 KB) - Retraction

Erratum: Rheb promotes cell growth as a component of the insulin/TOR signalling network - p680

doi:10.1038/ncb0703-680b

Full Text - Erratum: Rheb promotes cell growth as a component of the insulin/TOR signalling network | PDF (265 KB) - Erratum: Rheb promotes cell growth as a component of the insulin/TOR signalling network

Erratum: Distinct endocytic pathways regulate TGF- receptor signalling and turnover - p680

doi:10.1038/ncb0703-680c

Full Text - Erratum: Distinct endocytic pathways regulate TGF- receptor signalling and turnover | PDF (265 KB) - Erratum: Distinct endocytic pathways regulate TGF- receptor signalling and turnover

Corrigendum: RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase - p680

doi:10.1038/ncb0703-680d

Full Text - Corrigendum: RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase | PDF (265 KB) - Corrigendum: RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase

Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells - pp611 - 618

Yong-Hui Zheng, Hai-Feng Yu & B. Matija Peterlin

doi:10.1038/ncb1000

Abstract - Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells | Full Text - Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells | PDF (3,787 KB) - Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells

Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice - pp655 - 660

Norbert M. Wikonkal, Eva Remenyik, Dejan Knezevic, Wengeng Zhang, Ming Liu, Hongyu Zhao, T. R. Berton, David G. Johnson & Douglas E. Brash

doi:10.1038/ncb1001

First Paragraph - Inactivating : E2f1: reverts apoptosis resistance and cancer sensitivity in : Trp53: -deficient mice | Full Text - Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice | PDF (196 KB) - Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice

The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans - pp619 - 625

Jeffrey S. Simske, Mathias Köppen, Paul Sims, Jonathan Hodgkin, Alicia Yonkof & Jeff Hardin

doi:10.1038/ncb1002

First Paragraph - The cell junction protein VAB-9 regulates adhesion and epidermal morphology in : C. elegans | Full Text - The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans | PDF (2,132 KB) - The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans | Supplementary information

Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23 - pp661 - 667

Mickaël Cohen, Françoise Stutz, Naïma Belgareh, Rosine Haguenauer-Tsapis & Catherine Dargemont

doi:10.1038/ncb1003

First Paragraph - Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23 | Full Text - Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23 | PDF (840 KB) - Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23 | Supplementary information

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks - pp675 - 679

Arkady Celeste, Oscar Fernandez-Capetillo, Michael J. Kruhlak, Duane R. Pilch, David W. Staudt, Alicia Lee, Robert F. Bonner, William M. Bonner & André Nussenzweig

doi:10.1038/ncb1004

First Paragraph - Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks | Full Text - Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks | PDF (3,376 KB) - Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks | Supplementary information

Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK - pp647 - 654

Lindsey A. Allan, Nick Morrice, Suzanne Brady, Gareth Magee, Shalini Pathak & Paul R. Clarke

doi:10.1038/ncb1005

First Paragraph - Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK | Full Text - Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK | PDF (1,261 KB) - Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK | Supplementary information

Heritable gene silencing in lymphocytes delays chromatid resolution without affecting the timing of DNA replication - pp668 - 674

Véronique Azuara, Karen E. Brown, Ruth R. E. Williams, Natasha Webb, Niall Dillon, Richard Festenstein, Veronica Buckle, Matthias Merkenschlager & Amanda G. Fisher

doi:10.1038/ncb1006

First Paragraph - Heritable gene silencing in lymphocytes delays chromatid resolution without affecting the timing of DNA replication | Full Text - Heritable gene silencing in lymphocytes delays chromatid resolution without affecting the timing of DNA replication | PDF (3,245 KB) - Heritable gene silencing in lymphocytes delays chromatid resolution without affecting the timing of DNA replication | Supplementary information

Crosstalk between Rap1 and Rac regulates secretion of sAPP - pp633 - 639

Marjorie Maillet, Sylvain J. Robert, Mathias Cacquevel, Monique Gastineau, Denis Vivien, Jacques Bertoglio, José L. Zugaza, Rodolphe Fischmeister & Frank Lezoualc'h

doi:10.1038/ncb1007

First Paragraph - Crosstalk between Rap1 and Rac regulates secretion of sAPP[alpha] | Full Text - Crosstalk between Rap1 and Rac regulates secretion of sAPP | PDF (1,455 KB) - Crosstalk between Rap1 and Rac regulates secretion of sAPP | Supplementary information

Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential - pp640 - 646

Baohong Cao, Bo Zheng, Ron J. Jankowski, Shigemi Kimura, Makoto Ikezawa, Bridget Deasy, James Cummins, Mike Epperly, Zhuqing Qu-Petersen & Johnny Huard

doi:10.1038/ncb1008

First Paragraph - Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential | Full Text - Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential | PDF (1,060 KB) - Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential

Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization - pp626 - 632

Chieko Nakada, Kenneth Ritchie, Yuichi Oba, Mitsuhiro Nakamura, Yoko Hotta, Ryota Iino, Rinshi S. Kasai, Kazuhiko Yamaguchi, Takahiro Fujiwara & Akihiro Kusumi

doi:10.1038/ncb1009

First Paragraph - Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization | Full Text - Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization | PDF (2,081 KB) - Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization | Supplementary information