Table of contents


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Editorial

Editorial procedures reviewed pp583 - 584

doi:10.1038/ncb0703-583


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Book Review

Cell Biology online: Ergito p585

Eric Karsenti reviews

doi:10.1038/ncb0703-585


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News and Views

The yin and yang of E2F-1: balancing life and death pp587 - 589

Nicholas B. La Thangue

doi:10.1038/ncb0703-587

E2F transcription factors coordinate the timely expression of genes during early cell-cycle progression. In addition, the E2F-1 subunit can induce apoptosis in response to DNA damage. New results reveal an unexpected function for E2F-1 in suppressing apoptosis, which may be important in explaining the contribution of E2F-1 to tumorigenesis.


Movin' on through with Cdc2 pp589 - 590

Rudy Juliano

doi:10.1038/ncb0703-589

Proteins that control the cell cycle would seem to have little to do with cell migration. However, a recent report indicates that Cdc2, a key cyclin-dependent kinase, can also enhance cell migration. Levels of Cdc2 are upregulated in cells that express high levels of the alphavbeta3 integrin, a protein that has long been implicated in enhanced migration and invasion of tumour cells.


Recasting meiotic cohesion p591

Donald McDonald

doi:10.1038/ncb0703-591a


Neuronal polarization: building fences for molecular segregation pp591 - 594

Carlos G. Dotti & Mu-ming Poo

doi:10.1038/ncb0703-591b

Neurons exhibit distinct compositions in the axonal and dendrite plasma membrane, but it remains ambiguous whether or not a diffusion barrier is needed to keep the different components separated. Now, Nakada et al. utilize state of the art microscopy to follow the dynamics of single lipids or proteins inserted in different areas along the axonal and dendritic surface of neurons at different developmental stages. The results obtained shed new light on the mechanism underlying polarized segregation of membrane components in neurons.


A game of HIV and mouse p594

Bernd Pulverer

doi:10.1038/ncb0703-594


Claudin complexities at the apical junctional complex pp595 - 597

Ulrich Tepass

doi:10.1038/ncb0703-595

Chordate claudins are core components of tight junctions. By contrast, VAB-9, a nematode four-pass transmembrane protein related to claudins, localizes to adherens junctions and contributes to cell adhesion and actin–plasma membrane association.


Cell of the month: The vascular smooth muscle cell cytoskeleton p598

Mario Gimona

doi:10.1038/ncb0703-598


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Review

Conserved microtubule–actin interactions in cell movement and morphogenesis pp599 - 609

Olga C. Rodriguez, Andrew W. Schaefer, Craig A. Mandato, Paul Forscher, William M. Bement & Clare M. Waterman-Storer

doi:10.1038/ncb0703-599


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Retraction

Retraction p680

doi:10.1038/ncb0703-680a


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Letters

Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice pp655 - 660

Norbert M. Wikonkal, Eva Remenyik, Dejan Knezevic, Wengeng Zhang, Ming Liu, Hongyu Zhao, T. R. Berton, David G. Johnson & Douglas E. Brash

doi:10.1038/ncb1001



Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23 pp661 - 667

Mickaël Cohen, Françoise Stutz, Naïma Belgareh, Rosine Haguenauer-Tsapis & Catherine Dargemont

doi:10.1038/ncb1003


Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks pp675 - 679

Arkady Celeste, Oscar Fernandez-Capetillo, Michael J. Kruhlak, Duane R. Pilch, David W. Staudt, Alicia Lee, Robert F. Bonner, William M. Bonner & André Nussenzweig

doi:10.1038/ncb1004


Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK pp647 - 654

Lindsey A. Allan, Nick Morrice, Suzanne Brady, Gareth Magee, Shalini Pathak & Paul R. Clarke

doi:10.1038/ncb1005


Heritable gene silencing in lymphocytes delays chromatid resolution without affecting the timing of DNA replication pp668 - 674

Véronique Azuara, Karen E. Brown, Ruth R. E. Williams, Natasha Webb, Niall Dillon, Richard Festenstein, Veronica Buckle, Matthias Merkenschlager & Amanda G. Fisher

doi:10.1038/ncb1006


Crosstalk between Rap1 and Rac regulates secretion of sAPPalpha pp633 - 639

Marjorie Maillet, Sylvain J. Robert, Mathias Cacquevel, Monique Gastineau, Denis Vivien, Jacques Bertoglio, José L. Zugaza, Rodolphe Fischmeister & Frank Lezoualc'h

doi:10.1038/ncb1007


Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential pp640 - 646

Baohong Cao, Bo Zheng, Ron J. Jankowski, Shigemi Kimura, Makoto Ikezawa, Bridget Deasy, James Cummins, Mike Epperly, Zhuqing Qu-Petersen & Johnny Huard

doi:10.1038/ncb1008


Accumulation of anchored proteins forms membrane diffusion barriers during neuronal polarization pp626 - 632

Chieko Nakada, Kenneth Ritchie, Yuichi Oba, Mitsuhiro Nakamura, Yoko Hotta, Ryota Iino, Rinshi S. Kasai, Kazuhiko Yamaguchi, Takahiro Fujiwara & Akihiro Kusumi

doi:10.1038/ncb1009


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