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Letter
Nature Cell Biology 5, 675–679 (1 July 2003) | doi:10.1038/ncb1004
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
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Abstract
Histone H2AX is rapidly phosphorylated in the chromatin micro-environment surrounding a DNA double-strand break (DSB). Although H2AX deficiency is not detrimental to life, H2AX is required for the accumulation of numerous essential proteins into irradiation induced foci (IRIF).
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