Review abstract
Nature Cell Biology 5, 599 - 609 (2003)
doi:10.1038/ncb0703-599
Conserved microtubule–actin interactions in cell movement and morphogenesis
Olga C. Rodriguez1, Andrew W. Schaefer2, Craig A. Mandato3, Paul Forscher2, William M. Bement4 & Clare M. Waterman-Storer1
Abstract
Interactions between microtubules and actin are a basic phenomenon that underlies many fundamental processes in which dynamic cellular asymmetries need to be established and maintained. These are processes as diverse as cell motility, neuronal pathfinding, cellular wound healing, cell division and cortical flow. Microtubules and actin exhibit two mechanistic classes of interactions — regulatory and structural. These interactions comprise at least three conserved 'mechanochemical activity modules' that perform similar roles in these diverse cell functions.
- Olga C. Rodriguez and Clare M. Waterman-Storer are in Department of Cell Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
- Andrew W. Schaefer and Paul Forscher are in the Department of Molecular, Cellular and Developmental Biology, KBT222, Yale University, New Haven, CT 06520-8103, USA.
- Craig A. Mandato is in the Department of Anatomy and Cell Biology, McGill University, 3460 University Street, Montreal, PQ, H3A 2B2, Canada.
- William M. Bement is in the Department of Zoology and Program in Cellular and Molecular Biology, University of Wisconsin-Madison, 1117 West Johnson Street, Madison, WI 53706, USA.
Correspondence to: Clare M. Waterman-Storer1 e-mail: waterman@scripps.edu
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