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Nature Cell Biology 5, 589 - 590 (2003)
doi:10.1038/ncb0703-589
Movin' on through with Cdc2
Rudy Juliano1
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Rudy Juliano is in the Department of Pharmacology, University of North Carolina, 1106 Mary Ellen Jones Building, CB# 7365, Chapel Hill, NC 27599-7365, USA.
e-mail: arjay@med.unc.edu
Abstract
Proteins that control the cell cycle would seem to have little to do with cell migration. However, a recent report indicates that Cdc2, a key cyclin-dependent kinase, can also enhance cell migration. Levels of Cdc2 are upregulated in cells that express high levels of the 
v
3 integrin, a protein that has long been implicated in enhanced migration and invasion of tumour cells.
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