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Letter
Nature Cell Biology 5, 566–571 (1 June 2003) | doi:10.1038/ncb996
Rheb promotes cell growth as a component of the insulin/TOR signalling network
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Abstract
Insulin signalling is a potent inhibitor of cell growth and has been proposed to function, at least in part, through the conserved protein kinase TOR (target of rapamycin). Recent studies suggest a that the tuberous sclerosis complex Tsc1–Tsc2 may couple insulin signalling to Tor activity.
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