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Nature Cell Biology 5, 499–501 (1 June 2003) | doi:10.1038/ncb0603-499

Deconstructing phosphatases in limb development

Andrew T. Dudley & Clifford J. Tabin

The vertebrate limb bud is an important developmental context for understanding FGF signalling during embryogenesis. The limb bud is composed of mesenchyme (that gives rise to the limb skeleton) wrapped in a jacket of ectoderm.