Table of contents
June 2003, Volume 5 No 6 pp489-581
About the coverBook Review
Tips for youth - p491
Thomas B. L. Kirkwood reviews Ageless Quest: One Scientist's Search for Genes that Prolong Youth by Lenny Guarente
doi:10.1038/ncb0603-491
News and Views
The return of the exocyst - pp493 - 495
Casper C. Hoogenraad & Morgan Sheng
doi:10.1038/ncb0603-493
Changing the number of glutamate receptors (GluRs) in neuronal post-synaptic membranes is a critical way to alter the strength of synaptic transmission and is important for information storage in the brain. The molecular mechanisms regulating the delivery of GluRs to the synapse are emerging and a new link between NMDA-type GluRs, PSD-95-family scaffold proteins and the exocyst complex, reveals a novel pathway for synaptic trafficking.
Full Text - The return of the exocyst | PDF (282 KB) - The return of the exocyst
Reproductive cloning conserves cellular senescence - pp495 - 496
John M. Sedivy
doi:10.1038/ncb0603-495
Telomere shortening resulting from genome replication can trigger cellular senescence. In this issue Clark et al. show that rates of telomere attrition and the consequent replicative potential of cells are conserved during replicative cloning. This implies that these traits are genetically determined and raises interesting questions about their relationship to organismal phenotypes such as cancer, organ failure and ageing.
Full Text - Reproductive cloning conserves cellular senescence | PDF (124 KB) - Reproductive cloning conserves cellular senescence
Nuclear pore assembly: locating the linchpin - p497
Alison Schuldt
doi:10.1038/ncb0603-497a
Full Text - Nuclear pore assembly: locating the linchpin | PDF (215 KB) - Nuclear pore assembly: locating the linchpin
The cutting edge of mitochondrial fusion - pp497 - 499
Michael P. Yaffe
doi:10.1038/ncb0603-497b
Mitochondrial membrane fusion contributes to the shape and distribution of mitochondria in the eukaryotic cytoplasm. Recent work shows that a key component of the fusion reaction, Mgm1p, is activated by a novel mitochondrial protease related to the Drosophila melanogaster signalling protein Rhomboid.
Full Text - The cutting edge of mitochondrial fusion | PDF (315 KB) - The cutting edge of mitochondrial fusion
Deconstructing phosphatases in limb development - pp499 - 501
Andrew T. Dudley & Clifford J. Tabin
doi:10.1038/ncb0603-499
Signalling by growth factors, such as fibroblast growth factor (FGF), is critical for many of the morphogenetic events that shape the early embryo — including limb development. Recent findings regarding the regulation of FGF during limb development bridge the divide between results gained from in vitro biochemistry and the realities of in vivo development.
Full Text - Deconstructing phosphatases in limb development | PDF (172 KB) - Deconstructing phosphatases in limb development
Meddling with methylation - pp502 - 504
Chih-Lin Hsieh & Peter A. Jones
doi:10.1038/ncb0603-502
Covalent modification of DNA by methylation is crucial for maintaining the stability and structure of chromatin. Reports of the effects that altered methylation has for cancer development stress the importance of balanced genomic methylation.
Full Text - Meddling with methylation | PDF (420 KB) - Meddling with methylation
IKK
: a chromatin modifier - p503
Sowmya Swaminathan
doi:10.1038/ncb0603-503
Full Text - IKK
: a chromatin modifier | PDF (126 KB) - IKK: a chromatin modifier
Cell of the month: Crumbs and Moesin define Drosophila photoreceptor apical domains - p504
Sue A. Karagiosis
doi:10.1038/ncb0603-504
Full Text - Cell of the month: Crumbs and Moesin define Drosophila photoreceptor apical domains | PDF (281 KB) - Cell of the month: Crumbs and Moesin define Drosophila photoreceptor apical domains
Review
Polar expeditions — provisioning the centrosome for mitosis - pp505 - 511
Sarah P. Blagden & David M. Glover
doi:10.1038/ncb0603-505
Abstract - Polar expeditions [mdash] provisioning the centrosome for mitosis | Full Text - Polar expeditions — provisioning the centrosome for mitosis | PDF (581 KB) - Polar expeditions — provisioning the centrosome for mitosis
Articles
MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb - pp513 - 519
Yasuhiko Kawakami, Joaquín Rodríguez-León, Christopher M. Koth, Dirk Büscher, Tohru Itoh, Ángel Raya, Jennifer K. Ng, Concepción Rodríguez Esteban, Shigeru Takahashi, Domingos Henrique, May-Fun Schwarz, Hiroshi Asahara & Juan Carlos Izpisúa Belmonte
doi:10.1038/ncb989
Abstract - MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb | Full Text - MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb | PDF (735 KB) - MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb
See also: News and Views by Dudley & Tabin
NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex - pp520 - 530
Nathalie Sans, Kate Prybylowski, Ronald S. Petralia, Kai Chang, Ya-Xian Wang, Claudia Racca, Stefano Vicini & Robert J. Wenthold
doi:10.1038/ncb990
Abstract - NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex | Full Text - NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex | PDF (1,322 KB) - NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex
See also: News and Views by Hoogenraad & Sheng
Letters
Syntaxin specificity of cytokinesis in Arabidopsis - pp531 - 534
Isabel Müller, Wenke Wagner, Axel Völker, Swen Schellmann, Philippe Nacry, Frank Küttner, Zsuzsanna Schwarz-Sommer, Ulrike Mayer & Gerd Jürgens
doi:10.1038/ncb991
First Paragraph - Syntaxin specificity of cytokinesis in : Arabidopsis | Full Text - Syntaxin specificity of cytokinesis in Arabidopsis | PDF (817 KB) - Syntaxin specificity of cytokinesis in Arabidopsis | Supplementary information
Proliferative lifespan is conserved after nuclear transfer - pp535 - 538
A. John Clark, Patricia Ferrier, Samena Aslam, Sarah Burl, Chris Denning, Diana Wylie, Arlene Ross, Paul de Sousa, Ian Wilmut & Wei Cui
doi:10.1038/ncb992
First Paragraph - Proliferative lifespan is conserved after nuclear transfer | Full Text - Proliferative lifespan is conserved after nuclear transfer | PDF (186 KB) - Proliferative lifespan is conserved after nuclear transfer
See also: News and Views by Sedivy
Centrosome number is controlled by a centrosome-intrinsic block to reduplication - pp539 - 544
Connie Wong & Tim Stearns
doi:10.1038/ncb993
First Paragraph - Centrosome number is controlled by a centrosome-intrinsic block to reduplication | Full Text - Centrosome number is controlled by a centrosome-intrinsic block to reduplication | PDF (2,229 KB) - Centrosome number is controlled by a centrosome-intrinsic block to reduplication
Dual phosphorylation controls Cdc25 phosphatases and mitotic entry - pp545 - 551
Dmitry V. Bulavin, Yuichiro Higashimoto, Zoya N. Demidenko, Sarah Meek, Paul Graves, Crissy Phillips, Hui Zhao, Sally A. Moody, Ettore Appella, Helen Piwnica-Worms & Albert J. Fornace, Jr
doi:10.1038/ncb994
First Paragraph - Dual phosphorylation controls Cdc25 phosphatases and mitotic entry | Full Text - Dual phosphorylation controls Cdc25 phosphatases and mitotic entry | PDF (685 KB) - Dual phosphorylation controls Cdc25 phosphatases and mitotic entry | Supplementary information
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila - pp559 - 566
Hugo Stocker, Thomas Radimerski, Benno Schindelholz, Franz Wittwer, Priyanka Belawat, Pierre Daram, Sebastian Breuer, George Thomas & Ernst Hafen
doi:10.1038/ncb995
First Paragraph - Rheb is an essential regulator of S6K in controlling cell growth in : Drosophila | Full Text - Rheb is an essential regulator of S6K in controlling cell growth in Drosophila | PDF (2,445 KB) - Rheb is an essential regulator of S6K in controlling cell growth in Drosophila | Supplementary information
Rheb promotes cell growth as a component of the insulin/TOR signalling network - pp566 - 571
Leslie J. Saucedo, Xinsheng Gao, Dominic A. Chiarelli, Ling Li, Duoija Pan & Bruce A. Edgar
doi:10.1038/ncb996
First Paragraph - Rheb promotes cell growth as a component of the insulin/TOR signalling network | Full Text - Rheb promotes cell growth as a component of the insulin/TOR signalling network | PDF (1,343 KB) - Rheb promotes cell growth as a component of the insulin/TOR signalling network | Supplementary information
Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre - pp572 - 577
Michael Lisby, Uffe H. Mortensen & Rodney Rothstein
doi:10.1038/ncb997
First Paragraph - Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre | Full Text - Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre | PDF (2,469 KB) - Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre | Supplementary information
Differential regulation of E2F1 apoptotic target genes in response to DNA damage - pp552 - 558
Natalia Pediconi, Alessandra Ianari, Antonio Costanzo, Laura Belloni, Rita Gallo, Letizia Cimino, Antonio Porcellini, Isabella Screpanti, Clara Balsano, Edoardo Alesse, Alberto Gulino & Massimo Levrero
doi:10.1038/ncb998
First Paragraph - Differential regulation of E2F1 apoptotic target genes in response to DNA damage | Full Text - Differential regulation of E2F1 apoptotic target genes in response to DNA damage | PDF (283 KB) - Differential regulation of E2F1 apoptotic target genes in response to DNA damage | Supplementary information
Brief Communication
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins - pp578 - 581
Yong Zhang, Xinsheng Gao, Leslie J. Saucedo, Binggen Ru, Bruce A. Edgar & Duojia Pan
doi:10.1038/ncb999
Abstract - Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins | Full Text - Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins | PDF (195 KB) - Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins | Supplementary information
