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Letter

Nature Cell Biology 5, 552–558 (1 June 2003) | doi:10.1038/ncb998

Differential regulation of E2F1 apoptotic target genes in response to DNA damage

Natalia Pediconi , Alessandra Ianari , Antonio Costanzo , Laura Belloni , Rita Gallo , Letizia Cimino , Antonio Porcellini , Isabella Screpanti , Clara Balsano , Edoardo Alesse , Alberto Gulino & Massimo Levrero

E2F1, a member of the E2F family of transcription factors, in addition to its established proliferative effect, has also been implicated in the induction of apoptosis through p53-dependent and p53-independent pathways. Several genes involved in the activation or execution of the apoptotic programme have recently been shown to be upregulated at the transcriptional level by E2F1 overexpression, including the genes encoding INK4a/ARF, Apaf-1, caspase 7 and p73 (refs 3–5).