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Letter

Nature Cell Biology 5, 539–544 (1 June 2003) | doi:10.1038/ncb993

Centrosome number is controlled by a centrosome-intrinsic block to reduplication

Connie Wong & Tim Stearns

The centrosome duplicates once in S phase. To determine whether there is a block in centrosome reduplication, we used a cell fusion assay to compare the duplication potential of unduplicated G1 centrosomes and recently duplicated G2 centrosomes.