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Polar expeditions — provisioning the centrosome for mitosis

Nature Cell Biology volume 5, pages 505–511 (2003)Cite this article

Abstract

It is now clear that both centrioles and their surrounding pericentriolar material (PCM) are capable of self-assembly. Whereas centrioles are normally duplicated during G1–S phase, PCM components may be loaded onto centrosomes in both a microtubule-dependent and -independent manner at all stages of the cell cycle. Centrosomes enlarge dramatically after mitotic entry, when both Aurora A and Polo-like kinases cooperate to recruit additional γ-tubulin ring complexes and microtubule-associated proteins to assist spindle formation.

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Figure 1: Dynein-dependent and -independent routes for loading centrosomal components.
Figure 2: Polo kinase promotes the centrosomal association of γ-tubulin, and Aurora A kinase, D-TACC, in Drosophila mitotic cells.
Figure 3: Roles of Polo-like and Aurora A kinases in centrosomal maturation in Drosophila.

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  1. Department of Genetics, the Cancer Research UK Cell Cycle Genetics Research Group, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK

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Blagden, S., Glover, D. Polar expeditions — provisioning the centrosome for mitosis. Nat Cell Biol 5, 505–511 (2003). https://doi.org/10.1038/ncb0603-505

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