Article abstract
Nature Cell Biology 5, 520 - 530 (2003)
Published online: 12 May 2003 | doi:10.1038/ncb990
NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex
Nathalie Sans1, Kate Prybylowski1, Ronald S. Petralia1, Kai Chang1, Ya-Xian Wang1, Claudia Racca1, Stefano Vicini2 & Robert J. Wenthold1
Abstract
NMDA (N-methyl-D-aspartate) receptors (NMDARs) are targeted to dendrites and anchored at the post-synaptic density (PSD) through interactions with PDZ proteins. However, little is known about how these receptors are sorted from the endoplasmic reticulum and Golgi apparatus to the synapse. Here, we find that synapse-associated protein 102 (SAP102) interacts with the PDZ-binding domain of Sec8, a member of the exocyst complex. Our results show that interactions between SAP102 and Sec8 are involved in the delivery of NMDARs to the cell surface in heterologous cells and neurons. Furthermore, they suggest that an exocyst–SAP102–NMDAR complex is an important component of NMDAR trafficking.
- Laboratory of Neurochemistry, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Building 50, Room 4146, 50 South Drive, Bethesda, MD 20892-8027, USA.
- Department of Physiology and Biophysics, Georgetown University Medical Center, Room BSB225, 3900 Reservoir Road NW, Washington DC 20057-1421, USA
Correspondence to: Nathalie Sans1 e-mail: sansn@nidcd.nih.gov
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