Review abstract
Nature Cell Biology 5, 505 - 511 (2003)
doi:10.1038/ncb0603-505
Polar expeditions — provisioning the centrosome for mitosis
Sarah P. Blagden1 & David M. Glover1
Abstract
It is now clear that both centrioles and their surrounding pericentriolar material (PCM) are capable of self-assembly. Whereas centrioles are normally duplicated during G1–S phase, PCM components may be loaded onto centrosomes in both a microtubule-dependent and -independent manner at all stages of the cell cycle. Centrosomes enlarge dramatically after mitotic entry, when both Aurora A and Polo-like kinases cooperate to recruit additional 
-tubulin ring complexes and microtubule-associated proteins to assist spindle formation.
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Sarah P. Blagden and David M. Glover are in the Cancer Research UK Cell Cycle Genetics Research Group, University of Cambridge, Department of Genetics, Downing Street, Cambridge, CB2 3EH, UK.
e-mail: dmg25@cam.ac.uk
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