1. Chih-Lin Hsieh and Peter A. Jones are in the Departments of Biochemistry & Molecular Biology and Urology, USC/Norris Comprehensive Cancer Center, Los Angeles, CA 90089-9181, USA.
   e-mail: hsieh_c@ccnt.hsc.usc.edu
   e-mail: jones_p@ccnt.hsc.usc.edu

Abstract

Covalent modification of DNA by methylation is crucial for maintaining the stability and structure of chromatin. Reports of the effects that altered methylation has for cancer development stress the importance of balanced genomic methylation.

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