1. Casper C. Hoogenraad and Morgan Sheng are at The Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue (E18-215), Cambridge, MA 02139, USA.
   e-mail: msheng@mit.edu

Abstract

Changing the number of glutamate receptors (GluRs) in neuronal post-synaptic membranes is a critical way to alter the strength of synaptic transmission and is important for information storage in the brain. The molecular mechanisms regulating the delivery of GluRs to the synapse are emerging and a new link between NMDA-type GluRs, PSD-95-family scaffold proteins and the exocyst complex, reveals a novel pathway for synaptic trafficking.

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