Access

News and Views

Nature Cell Biology 5, 373–376 (1 May 2003) | doi:10.1038/ncb0503-373

The N-end rule and regulation of apoptosis

Alexander Varshavsky

Apoptosis (programmed cell death) in a multicellular organism makes possible the selective elimination of supernumerary, damaged or otherwise abnormal cells. In most cases, the apoptotic death of a cell is caused by the activity of caspases, a set of sequence-specific intracellular proteases that are normally dormant, but which can be activated by signals that induce apoptosis.