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Nature Cell Biology 5, 390 - 393 (2003)
doi:10.1038/ncb0503-390
Memorable transcription
Bryan M. Turner1
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Bryan Turner is at the Chromatin and Gene Expression Group, Anatomy Department, University of Birmingham Medical School, Birmingham B15 2TT, United Kingdom.
e-mail: b.m.turner@bham.ac.uk
Abstract
Experiments in the yeast Saccharomyces cerevisiae have shown that the enzyme Set1 preferentially targets the 5' coding regions of transcriptionally active genes, where it catalyses di- and tri-methylation of histone H3 Lys 4. This methylation mark is retained after transcription has subsided, suggesting that it provides a memory of recent transcription.
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