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News and Views
Nature Cell Biology  5, 385 - 387 (2003)
doi:10.1038/ncb0503-385

Deafening cycle

Bridget Baumgartner1 & J. Wade Harper2

1  Bridget Baumgartner is in the Program in Cellular and Molecular Biology, One Baylor Plaza, Baylor College of Medicine, Houston, TX 777030, USA.

2  J. Wade Harper is in the Program in Cellular and Molecular Biology, Department of Biochemistry and Molecular Biology and Department of Molecular Physiology and Biophysics, One Baylor Plaza, Baylor College of Medicine, Houston, TX 777030, USA.
jharper@bcm.tmc.edu

Hearing loss in mammals occurs when auditory hair cells, specialized in the detection of sound waves, undergo irreversible damage. However, the mechanism, and in particular the genetic basis of the process, is poorly understood. A study in this issue now shows that functional inactivation of the cyclin D-dependent kinase inhibitor Ink4d results in progressive hearing loss in mice, implicating Cdk inhibitors and inappropriate hair cell proliferation in deafness.

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