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Nature Cell Biology 5, 382 - 384 (2003)
doi:10.1038/ncb0503-382

Sliding doors: clathrin-coated pits or caveolae?

Michela Felberbaum-Corti1, Françoise Gisou Van Der Goot2 & Jean Gruenberg1

  1. Michela Felberbaum-Corti and Jean Gruenberg are in the Department of Biochemistry, Sciences II, 30 quai E. Ansermet, CH-1211 Geneva 4, Switzerland.
    e-mail: jean.gruenberg@biochem.unige.ch
  2. Françoise Gisou Van Der Goot is in the Department of Genetics and Microbiology, CMU, 1, rue Michel-Servet, CH-1211 Geneva 4, Switzerland.

Some cell-surface receptors activate downstream signal transduction pathways not only from the cell surface but also from endosomes, suggesting that signalling pathways can be regulated by compartmentalization. A further twist is that different internalization routes seem to predetermine whether transforming growth factor beta (TGF-beta) receptors will trigger a signalling response or be degraded.

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