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Nature Cell Biology 5, 377 - 379 (2003)
doi:10.1038/ncb0503-377

Split personalities: the agonistic antagonist Sprouty

Gerhard Christofori1

  1. Gerhard Christofori is in the Institute of Biochemistry and Genetics, Department of Clinical-Biological Sciences, University of Basel, Vesalgasse 1, CH-4051 Basel, Switzerland.
    e-mail: gerhard.christofori@unibas.ch

Sprouty proteins are antagonists of receptor tyrosine kinase (RTK) signalling in a number of developmental and physiological processes. A collection of work indicates that Sprouty proteins negatively and positively modulate RTK-induced signalling pathways through various mechanisms, thereby combining a variety of cellular functions in one molecule.

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