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Nature Cell Biology 5, 373 - 376 (2003)
doi:10.1038/ncb0503-373

The N-end rule and regulation of apoptosis

Alexander Varshavsky1

  1. Alexander Varshavsky is in the Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA.
    e-mail: avarsh@caltech.edu

The ubiquitin-dependent N-end rule pathway targets proteins for degradation through their destabilizing N-terminal residues. This pathway is known to control the import of peptides, chromosome stability and cardiovascular development. A new report identifies yet another function of the N-end rule pathway: the regulation of apoptosis through degradation of Drosophila melanogaster DIAP1.

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