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Letter

Nature Cell Biology 5, 336–340 (1 April 2003) | doi:10.1038/ncb952

Identification of the ubiquitin|[ndash]|protein ligase that recognizes oxidized IRP2

Koji Yamanaka , Haruto Ishikawa , Yuzuru Megumi , Fuminori Tokunaga , Masato Kanie , Tracey A. Rouault , Isao Morishima , Nagahiro Minato , Koichiro Ishimori & Kazuhiro Iwai

The ubiquitin system is involved in several basic cellular functions. Ubiquitination is carried out by a cascade of three reactions catalysed by the E1, E2 and E3 enzymes.