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Nature Cell Biology 5, 278 - 280 (2003)
doi:10.1038/ncb0403-278
Anti-silencing from the core: a histone H2A variant protects euchromatin
- Marc Hild and Renato Paro are in Zentrum für Molekulare Biologie Heidelberg (ZMBH), University of Heidelberg, Im Neuenheimer Feld 282, 69120 Heidelberg, Germany.
Correspondence to: Renato Paro1 e-mail: paro@sun0.urz.uni-heidelberg.de
Abstract
To coordinate the coding complexity of the eukaryotic genome, mechanisms have evolved that protect active genes from silent chromatin structures such as heterochromatin. Although post-translational modifications of histone tails can regulate chromatin states, a new report now demonstrates that the composition of the nucleosome itself is also important for maintaining chromatin states.
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