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Nature Cell Biology 5, 273 - 274 (2003)
doi:10.1038/ncb0403-273
A lethal giant kinase in cell polarity
Nicholas J. Justice1 & Yuh Nung Jan1
- Nicholas J. Justice and Yuh Nung Jan are at the Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California at San Francisco, San Francisco, CA 94143-0725, USA
Correspondence to: Nicholas J. Justice1 e-mail: njustice@phy.ucsf.edu
Abstract
The coordinated action of several conserved multiprotein complexes establishes polarity in an asymmetrically dividing cell. How apically localized cues affect the basal distribution of proteins has remained unclear. However, new studies provides a direct link between the two poles, showing that the apical Par6–aPKC complex directly regulates Lethal giant larvae (Lgl).
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