Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Article
Nature Cell Biology 5, 195–204 (1 March 2003) | doi:10.1038/ncb935
RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase
&
Abstract
Early endosomes move bidirectionally between the cell periphery and the interior through a mechanism regulated by the low molecular weight GTPase RhoD. Here, we identify a novel splice variant of human Diaphanous, hDia2C, which specifically binds to RhoD and is recruited onto early endosomes. Expression of RhoD and hDia2C induces a striking alignment of early endosomes along actin filaments and reduces their motility. This activity depends on the membrane recruitment and activation of c-Src kinase, thus uncovering a new role in endosome function. Our results define a novel signal transduction pathway, in which hDia2C and c-Src are sequentially activated by RhoD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
