Evolving NCB - p173

doi:10.1038/ncb0303-173

Full Text - Evolving NCB | PDF (138 KB) - Evolving NCB

Dynamic proteins and a cytoskeleton in bacteria - pp175 - 178

Jeffery Errington

doi:10.1038/ncb0303-175

The application of modern fluorescence microscopic methods to bacteria has revolutionized our view of their subcellular organization. Many proteins are now known to be targeted with exquisite precision to specific locations in the cell, or to undergo rapid directed changes in localization. Structural and functional homologues of tubulin (FtsZ) and actin (MreB) are now indisputably present in bacteria, overturning the textbook view that the cytoskeleton is unique to eukaryotes. These advances are stimulating a radical rethink about how various fundamental processes are organised in bacteria.

Full Text - Dynamic proteins and a cytoskeleton in bacteria | PDF (448 KB) - Dynamic proteins and a cytoskeleton in bacteria

Armadillo/-catenin signals in the nucleus – proof beyond a reasonable doubt? - pp179 - 182

Mariann Bienz & Hans Clevers

doi:10.1038/ncb0303-179

Abstract - | Full Text - Armadillo/-catenin signals in the nucleus – proof beyond a reasonable doubt? | PDF (488 KB) - Armadillo/-catenin signals in the nucleus – proof beyond a reasonable doubt?

A nucleolar disappearing act in somatic cloning - pp183 - 184

Tom Misteli

doi:10.1038/ncb0303-183

One of the earliest structural changes in cloning by nuclear transfer is the disassembly of the nucleolus. The first insights into the molecular mechanisms of this event have now emerged and the results have tantalising implications for nucleolar architecture.

Full Text - A nucleolar disappearing act in somatic cloning | PDF (181 KB) - A nucleolar disappearing act in somatic cloning

Rac signalling: a radical view - pp185 - 187

Emmanuelle Caron

doi:10.1038/ncb0303-185

GTP-binding proteins of the Rho family regulate each other's activities by largely elusive mechanisms. Now, an unexpected signalling pathway has been identified in fibroblasts that links Rac activation to the inhibition of Rho activity, through the release of oxygen radicals.

Full Text - Rac signalling: a radical view | PDF (151 KB) - Rac signalling: a radical view

RNA repaired - p187

Bernd Pulverer

doi:10.1038/ncb0303-187

Full Text - RNA repaired | PDF (130 KB) - RNA repaired

Multitasking at mitotic exit - pp188 - 190

Karen E. Ross & Orna Cohen-Fix

doi:10.1038/ncb0303-188

Separase is a conserved protease that activates the metaphase-to-anaphase transition by cleaving the link between sister chromatids. Furthermore, in Saccharomyces cerevisiae, separase is also involved in promoting mitotic exit through regulating Cdc14 release. A new study now suggests that the mitotic exit function of separase is independent from its protease activity.

Full Text - Multitasking at mitotic exit | PDF (207 KB) - Multitasking at mitotic exit

GNOM alone - p189

Donald Mcdonald

doi:10.1038/ncb0303-189

Full Text - GNOM alone | PDF (153 KB) - GNOM alone

The multiple functions of tumour suppressors: it's all in APC - pp190 - 192

Riccardo Fodde

doi:10.1038/ncb0303-190

The multi-functionality of the adenomatous polyposis coli (APC) tumour suppressor gene keeps surprising cancer molecular biologists. Signal transduction, cytoskeletal organization, chromosomal segregation and cell adhesion are just some of the putative cellular functions previously assigned to this gene and thought to be related to its tumour-suppressing activity. New data on yet another tumour-related function of APC, namely the coordinated regulation of cell adhesion and motility, adds to its host of cellular activities.

Full Text - The multiple functions of tumour suppressors: it's all in APC | PDF (114 KB) - The multiple functions of tumour suppressors: it's all in APC

Cell of the month: Nuclear pore complexes and Cajal bodies in Xenopus laevis oocytes - p193

Elena Kiseleva

doi:10.1038/ncb0303-193

Full Text - Cell of the month: Nuclear pore complexes and Cajal bodies in Xenopus laevis oocytes | PDF (644 KB) - Cell of the month: Nuclear pore complexes and Cajal bodies in Xenopus laevis oocytes

A walk on the wild side (of the synapse) - p194

Mark von Zastrow reviews Receptor and Ion-Channel Trafficking: Cell biology of ligand-gated and voltage-sensitive ion channels by Stephen J. Moss & Jeremy Henley

doi:10.1038/ncb0303-194

Full Text - A walk on the wild side (of the synapse) | PDF (106 KB) - A walk on the wild side (of the synapse)

RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase - pp195 - 204

Stéphane Gasman, Yannis Kalaidzidis & Marino Zerial

doi:10.1038/ncb935

Abstract - | Full Text - RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase | PDF (1,535 KB) - RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase | Supplementary information

Reversible disassembly of somatic nucleoli by the germ cell proteins FRGY2a and FRGY2b - pp205 - 210

Koichi Gonda, Jason Fowler, Nobuko Katoku-Kikyo, Jennifer Haroldson, Justin Wudel & Nobuaki Kikyo

doi:10.1038/ncb939

First Paragraph - | Full Text - Reversible disassembly of somatic nucleoli by the germ cell proteins FRGY2a and FRGY2b | PDF (605 KB) - Reversible disassembly of somatic nucleoli by the germ cell proteins FRGY2a and FRGY2b | Supplementary information

Mutated APC and Asef are involved in the migration of colorectal tumour cells - pp211 - 215

Yoshihiro Kawasaki, Rina Sato & Tetsu Akiyama

doi:10.1038/ncb937

First Paragraph - | Full Text - Mutated APC and Asef are involved in the migration of colorectal tumour cells | PDF (447 KB) - Mutated APC and Asef are involved in the migration of colorectal tumour cells

p53RDL1 regulates p53-dependent apoptosis - pp216 - 223

Chizu Tanikawa, Koichi Matsuda, Seisuke Fukuda, Yusuke Nakamura & Hirofumi Arakawa

doi:10.1038/ncb943

First Paragraph - | Full Text - p53RDL1 regulates p53-dependent apoptosis | PDF (434 KB) - p53RDL1 regulates p53-dependent apoptosis | Supplementary information

Cytokines suppress adipogenesis and PPAR- function through the TAK1/TAB1/NIK cascade - pp224 - 230

Miyuki Suzawa, Ichiro Takada, Junn Yanagisawa, Fumiaki Ohtake, Satoko Ogawa, Toshimasa Yamauchi, Takashi Kadowaki, Yasuhiro Takeuchi, Hiroshi Shibuya, Yukiko Gotoh, Kunihiro Matsumoto & Shigeaki Kato

doi:10.1038/ncb942

First Paragraph - | Full Text - Cytokines suppress adipogenesis and PPAR- function through the TAK1/TAB1/NIK cascade | PDF (1,253 KB) - Cytokines suppress adipogenesis and PPAR- function through the TAK1/TAB1/NIK cascade

Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant - pp231 - 235

Daria E. Siekhaus & David G. Drubin

doi:10.1038/ncb941

First Paragraph - | Full Text - Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant | PDF (728 KB) - Spontaneous receptor-independent heterotrimeric G-protein signalling in an RGS mutant | Supplementary information

Redox-dependent downregulation of Rho by Rac - pp236 - 241

Anjaruwee S. Nimnual, Laura J. Taylor & Dafna Bar-Sagi

doi:10.1038/ncb938

First Paragraph - | Full Text - Redox-dependent downregulation of Rho by Rac | PDF (1,487 KB) - Redox-dependent downregulation of Rho by Rac | Supplementary information

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly - pp242 - 248

Ming-Ying Tsai, Christiane Wiese, Kan Cao, Ona Martin, Peter Donovan, Joan Ruderman, Claude Prigent & Yixian Zheng

doi:10.1038/ncb936

First Paragraph - | Full Text - A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly | PDF (313 KB) - A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly

A non-proteolytic function of separase links the onset of anaphase to mitotic exit - pp249 - 254

Matt Sullivan & Frank Uhlmann

doi:10.1038/ncb940

Abstract - | Full Text - A non-proteolytic function of separase links the onset of anaphase to mitotic exit | PDF (470 KB) - A non-proteolytic function of separase links the onset of anaphase to mitotic exit | Supplementary information

Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage - pp255 - 260

Claudia Lukas, Jacob Falck, Jirina Bartkova, Jiri Bartek & Jiri Lukas

doi:10.1038/ncb945

First Paragraph - | Full Text - Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage | PDF (8,537 KB) - Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage | Supplementary information

The spindle-associated transmembrane protein Axs identifies a membranous structure ensheathing the meiotic spindle - pp261 - 263

Joseph Kramer & R. Scott Hawley

doi:10.1038/ncb944

Abstract - | Full Text - The spindle-associated transmembrane protein Axs identifies a membranous structure ensheathing the meiotic spindle | PDF (696 KB) - The spindle-associated transmembrane protein Axs identifies a membranous structure ensheathing the meiotic spindle | Supplementary information

Erratum: Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69 - p264

doi:10.1038/ncb946

Full Text - Erratum: Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69 | PDF (98 KB) - Erratum: Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69

Erratum: Yeast epsin-related proteins required for Golgi–endosome traffic define a -adaptin ear-binding motif - p264

doi:10.1038/ncb947

Full Text - Erratum: Yeast epsin-related proteins required for Golgi–endosome traffic define a -adaptin ear-binding motif | PDF (50 KB) - Erratum: Yeast epsin-related proteins required for Golgi–endosome traffic define a -adaptin ear-binding motif