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Nature Cell Biology 5, 190 - 192 (2003)
doi:10.1038/ncb0303-190

The multiple functions of tumour suppressors: it's all in APC

Riccardo Fodde1

  1. Riccardo Fodde is in the Center for Human & Clinical Genetics, Leiden University Medical Center, Leiden, 2300 RA, The Netherlands
    e-mail: r.fodde@lumc.nl

The multi-functionality of the adenomatous polyposis coli (APC) tumour suppressor gene keeps surprising cancer molecular biologists. Signal transduction, cytoskeletal organization, chromosomal segregation and cell adhesion are just some of the putative cellular functions previously assigned to this gene and thought to be related to its tumour-suppressing activity. New data on yet another tumour-related function of APC, namely the coordinated regulation of cell adhesion and motility, adds to its host of cellular activities.

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