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Nature Cell Biology 5, 188 - 190 (2003)
doi:10.1038/ncb0303-188
Multitasking at mitotic exit
Karen E. Ross1 & Orna Cohen-Fix1
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Karen E. Ross and Orna Cohen-Fix are in the Laboratory of Molecular and Cellular Biology, National Institute of Diabetes and Digestive Kidney Disease, The National Institutes of Health, 8 Center Drive, Bethesda MD, 20892, USA
e-mail: kross@helix.nih.gov or e-mail: ornacf@helix.nih.gov
Abstract
Separase is a conserved protease that activates the metaphase-to-anaphase transition by cleaving the link between sister chromatids. Furthermore, in Saccharomyces cerevisiae, separase is also involved in promoting mitotic exit through regulating Cdc14 release. A new study now suggests that the mitotic exit function of separase is independent from its protease activity.
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