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Nature Cell Biology 5, 185 - 187 (2003)
doi:10.1038/ncb0303-185
Rac signalling: a radical view
Emmanuelle Caron1
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Emmanuelle Caron is at the Centre for Molecular Microbiology and Infection & the Department of Biological Sciences, The Flowers Building, Room 2:41, Armstrong Road, Imperial College London, London SW7 2AZ, UK
e-mail: e.caron@imperial.ac.uk
Abstract
GTP-binding proteins of the Rho family regulate each other's activities by largely elusive mechanisms. Now, an unexpected signalling pathway has been identified in fibroblasts that links Rac activation to the inhibition of Rho activity, through the release of oxygen radicals.
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