Cloning terror - pp85 - 86

doi:10.1038/ncb0203-85

Full Text - Cloning terror | PDF (77 KB) - Cloning terror

Signalling pathways that mediate skeletal muscle hypertrophy and atrophy - pp87 - 90

David J. Glass

doi:10.1038/ncb0203-87

Abstract - | Full Text - Signalling pathways that mediate skeletal muscle hypertrophy and atrophy | PDF (103 KB) - Signalling pathways that mediate skeletal muscle hypertrophy and atrophy

Killer wiles: growing interest in Fas - pp91 - 92

Brigitte Pettmann & Christopher E. Henderson

doi:10.1038/ncb0203-91

Signalling pathways involved in axonal growth are the subject of intense study. A new report further highlights the role of the extracellular signal-regulated kinase (ERK)/p35 pathway, but identifies a surprising potential trigger: the death receptor Fas. This study illustrates the importance of cellular context in the functional outcome of a given signalling mechanism.

Full Text - Killer wiles: growing interest in Fas | PDF (168 KB) - Killer wiles: growing interest in Fas

How to attract a sperm - pp93 - 96

Jackson C. Kirkman-Brown, Keith A. Sutton & Harvey M. Florman

doi:10.1038/ncb0203-93

One of the most fundamental questions of fertilization is how do sperm locate eggs? In many animals and lower plant groups, sperm are guided by chemo-attractants released from eggs. In this issue of Nature Cell Biology, Kaupp and colleagues now examine the very early events of this process in the sea urchin Arbacia punctulata.

Full Text - How to attract a sperm | PDF (149 KB) - How to attract a sperm

Caveat experimentor — is your myosin really inhibited? - p95

Margareta A. Titus

doi:10.1038/ncb0203-95

Full Text - Caveat experimentor — is your myosin really inhibited? | PDF (67 KB) - Caveat experimentor — is your myosin really inhibited?

ATMachine - p96

Bernd Pulverer

doi:10.1038/ncb0203-96

Full Text - ATMachine | PDF (92 KB) - ATMachine

Mitochondria, AIF and caspases — rivaling for cell death execution - pp97 - 99

Josef M. Penninger & Guido Kroemer

doi:10.1038/ncb0203-97

In both the nematode Caenorhabditis elegans and mammals, two proteins released from the mitochondrion — apoptosis inducing factor (AIF) and endonuclease G — cooperate in executing programmed cell death. Although both factors can kill cells in a caspase-independent fashion, new studies indicate that their translocation from mitochondria depends, in part, on caspase activation. Together, these data raise new questions about the functional hierarchy between caspases, AIF and mitochondrial membrane permeabilization.

Full Text - Mitochondria, AIF and caspases — rivaling for cell death execution | PDF (219 KB) - Mitochondria, AIF and caspases — rivaling for cell death execution

Cell of the month: Two telophase HeLa cells expressing GFP–tagged human Aurora B - p101

doi:10.1038/ncb0203-101

Full Text - Cell of the month: Two telophase HeLa cells expressing GFP–tagged human Aurora B | PDF (432 KB) - Cell of the month: Two telophase HeLa cells expressing GFP–tagged human Aurora B

Tools for Complexity - p102

Robert D. Phair reviews Computational Cell Biology by C.P. Fall, E.S. Marland, J.M. Wagner & J.J. Tyson

doi:10.1038/ncb0203-102

Full Text - Tools for Complexity | PDF (121 KB) - Tools for Complexity

Developmental control of cell morphogenesis: a focus on membrane growth - pp103 - 108

Thomas Lecuit & Fanny Pilot

doi:10.1038/ncb0203-103

Abstract - | Full Text - Developmental control of cell morphogenesis: a focus on membrane growth | PDF (1,902 KB) - Developmental control of cell morphogenesis: a focus on membrane growth

The signal flow and motor response controling chemotaxis of sea urchin sperm - pp109 - 117

U. Benjamin Kaupp, Johannes Solzin, Eilo Hildebrand, Joel E. Brown, Annika Helbig, Volker Hagen, Michael Beyermann, Francesco Pampaloni & Ingo Weyand

doi:10.1038/ncb915

Abstract - | Full Text - The signal flow and motor response controling chemotaxis of sea urchin sperm | PDF (1,116 KB) - The signal flow and motor response controling chemotaxis of sea urchin sperm | Supplementary information

Fas engagement induces neurite growth through ERK activation and p35 upregulation - pp118 - 125

Julie Desbarats, Raymond B. Birge, Manuelle Mimouni-Rongy, David E. Weinstein, Jean-Sébastien Palerme & M. Karen Newell

doi:10.1038/ncb916

Abstract - | Full Text - Fas engagement induces neurite growth through ERK activation and p35 upregulation | PDF (6,233 KB) - Fas engagement induces neurite growth through ERK activation and p35 upregulation

Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells - pp126 - 136

Geri Kreitzer, Jan Schmoranzer, Seng Hui Low, Xin Li, Yunbo Gan, Thomas Weimbs, Sanford M Simon & Enrique Rodriguez-Boulan

doi:10.1038/ncb917

Abstract - | Full Text - Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells | PDF (3,108 KB) - Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells | Supplementary information

Direct interaction of two polarity complexes implicated in epithelial tight junction assembly - pp137 - 142

Toby W. Hurd, Lin Gao, Michael H. Roh, Ian G. Macara & Ben Margolis

doi:10.1038/ncb923

First Paragraph - | Full Text - Direct interaction of two polarity complexes implicated in epithelial tight junction assembly | PDF (1,179 KB) - Direct interaction of two polarity complexes implicated in epithelial tight junction assembly

Active cyclin B1–Cdk1 first appears on centrosomes in prophase - pp143 - 148

Mark Jackman, Catherine Lindon, Erich A. Nigg & Jonathon Pines

doi:10.1038/ncb918

First Paragraph - | Full Text - Active cyclin B1–Cdk1 first appears on centrosomes in prophase | PDF (1,401 KB) - Active cyclin B1–Cdk1 first appears on centrosomes in prophase | Supplementary information

Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation - pp149 - 154

Sylvain Latour, Romain Roncagalli, Riyan Chen, Marcin Bakinowski, Xiaochu Shi, Pamela L. Schwartzberg, Dominique Davidson & André Veillette

doi:10.1038/ncb919

First Paragraph - | Full Text - Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation | PDF (617 KB) - Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

SAP couples Fyn to SLAM immune receptors - pp155 - 160

Betty Chan, Arpad Lanyi, Hyun Kyu Song, Jan Griesbach, Maria Simarro-Grande, Florence Poy, Duncan Howie, Janos Sumegi, Cox Terhorst & Michael J. Eck

doi:10.1038/ncb920

First Paragraph - | Full Text - SAP couples Fyn to SLAM immune receptors | PDF (1,095 KB) - SAP couples Fyn to SLAM immune receptors

Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1 - pp161 - 165

Akiko Kumagai & William G. Dunphy

doi:10.1038/ncb921

First Paragraph - | Full Text - Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1 | PDF (1,372 KB) - Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1 | Supplementary information

Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry - pp166 - 170

Roger Albertson & Chris Q. Doe

doi:10.1038/ncb922

First Paragraph - | Full Text - Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry | PDF (2,916 KB) - Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry | Supplementary information

Native Myosin-IXb is a plus-, not a minus-end-directed motor - pp171 - 172

Christopher B. O'Connell & Mark S. Mooseker

doi:10.1038/ncb924

Abstract - | Full Text - Native Myosin-IXb is a plus-, not a minus-end-directed motor | PDF (279 KB) - Native Myosin-IXb is a plus-, not a minus-end-directed motor | Supplementary information