Table of contents
February 2003, Volume 5 No 2 pp85-172
About the coverPerspective
Signalling pathways that mediate skeletal muscle hypertrophy and atrophy - pp87 - 90
David J. Glass
doi:10.1038/ncb0203-87
Abstract - | Full Text - Signalling pathways that mediate skeletal muscle hypertrophy and atrophy | PDF (103 KB) - Signalling pathways that mediate skeletal muscle hypertrophy and atrophy
News and Views
Killer wiles: growing interest in Fas - pp91 - 92
Brigitte Pettmann & Christopher E. Henderson
doi:10.1038/ncb0203-91
Signalling pathways involved in axonal growth are the subject of intense study. A new report further highlights the role of the extracellular signal-regulated kinase (ERK)/p35 pathway, but identifies a surprising potential trigger: the death receptor Fas. This study illustrates the importance of cellular context in the functional outcome of a given signalling mechanism.
Full Text - Killer wiles: growing interest in Fas | PDF (168 KB) - Killer wiles: growing interest in Fas
How to attract a sperm - pp93 - 96
Jackson C. Kirkman-Brown, Keith A. Sutton & Harvey M. Florman
doi:10.1038/ncb0203-93
One of the most fundamental questions of fertilization is how do sperm locate eggs? In many animals and lower plant groups, sperm are guided by chemo-attractants released from eggs. In this issue of Nature Cell Biology, Kaupp and colleagues now examine the very early events of this process in the sea urchin Arbacia punctulata.
Full Text - How to attract a sperm | PDF (149 KB) - How to attract a sperm
Caveat experimentor — is your myosin really inhibited? - p95
Margareta A. Titus
doi:10.1038/ncb0203-95
Full Text - Caveat experimentor — is your myosin really inhibited? | PDF (67 KB) - Caveat experimentor — is your myosin really inhibited?
Mitochondria, AIF and caspases — rivaling for cell death execution - pp97 - 99
Josef M. Penninger & Guido Kroemer
doi:10.1038/ncb0203-97
In both the nematode Caenorhabditis elegans and mammals, two proteins released from the mitochondrion — apoptosis inducing factor (AIF) and endonuclease G — cooperate in executing programmed cell death. Although both factors can kill cells in a caspase-independent fashion, new studies indicate that their translocation from mitochondria depends, in part, on caspase activation. Together, these data raise new questions about the functional hierarchy between caspases, AIF and mitochondrial membrane permeabilization.
Full Text - Mitochondria, AIF and caspases — rivaling for cell death execution | PDF (219 KB) - Mitochondria, AIF and caspases — rivaling for cell death execution
Cell of the month: Two telophase HeLa cells expressing GFP–tagged human Aurora B - p101
doi:10.1038/ncb0203-101
Full Text - Cell of the month: Two telophase HeLa cells expressing GFP–tagged human Aurora B | PDF (432 KB) - Cell of the month: Two telophase HeLa cells expressing GFP–tagged human Aurora B
Book Review
Tools for Complexity - p102
Robert D. Phair reviews Computational Cell Biology by C.P. Fall, E.S. Marland, J.M. Wagner & J.J. Tyson
doi:10.1038/ncb0203-102
Full Text - Tools for Complexity | PDF (121 KB) - Tools for Complexity
Review
Developmental control of cell morphogenesis: a focus on membrane growth - pp103 - 108
Thomas Lecuit & Fanny Pilot
doi:10.1038/ncb0203-103
Abstract - | Full Text - Developmental control of cell morphogenesis: a focus on membrane growth | PDF (1,902 KB) - Developmental control of cell morphogenesis: a focus on membrane growth
Articles
The signal flow and motor response controling chemotaxis of sea urchin sperm - pp109 - 117
U. Benjamin Kaupp, Johannes Solzin, Eilo Hildebrand, Joel E. Brown, Annika Helbig, Volker Hagen, Michael Beyermann, Francesco Pampaloni & Ingo Weyand
doi:10.1038/ncb915
Abstract - | Full Text - The signal flow and motor response controling chemotaxis of sea urchin sperm | PDF (1,116 KB) - The signal flow and motor response controling chemotaxis of sea urchin sperm | Supplementary information
Fas engagement induces neurite growth through ERK activation and p35 upregulation - pp118 - 125
Julie Desbarats, Raymond B. Birge, Manuelle Mimouni-Rongy, David E. Weinstein, Jean-Sébastien Palerme & M. Karen Newell
doi:10.1038/ncb916
Abstract - | Full Text - Fas engagement induces neurite growth through ERK activation and p35 upregulation | PDF (6,233 KB) - Fas engagement induces neurite growth through ERK activation and p35 upregulation
Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells - pp126 - 136
Geri Kreitzer, Jan Schmoranzer, Seng Hui Low, Xin Li, Yunbo Gan, Thomas Weimbs, Sanford M Simon & Enrique Rodriguez-Boulan
doi:10.1038/ncb917
Abstract - | Full Text - Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells | PDF (3,108 KB) - Three-dimensional analysis of post-Golgi carrier exocytosis in epithelial cells | Supplementary information
Letters
Direct interaction of two polarity complexes implicated in epithelial tight junction assembly - pp137 - 142
Toby W. Hurd, Lin Gao, Michael H. Roh, Ian G. Macara & Ben Margolis
doi:10.1038/ncb923
First Paragraph - | Full Text - Direct interaction of two polarity complexes implicated in epithelial tight junction assembly | PDF (1,179 KB) - Direct interaction of two polarity complexes implicated in epithelial tight junction assembly
Active cyclin B1–Cdk1 first appears on centrosomes in prophase - pp143 - 148
Mark Jackman, Catherine Lindon, Erich A. Nigg & Jonathon Pines
doi:10.1038/ncb918
First Paragraph - | Full Text - Active cyclin B1–Cdk1 first appears on centrosomes in prophase | PDF (1,401 KB) - Active cyclin B1–Cdk1 first appears on centrosomes in prophase | Supplementary information
Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation - pp149 - 154
Sylvain Latour, Romain Roncagalli, Riyan Chen, Marcin Bakinowski, Xiaochu Shi, Pamela L. Schwartzberg, Dominique Davidson & André Veillette
doi:10.1038/ncb919
First Paragraph - | Full Text - Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation | PDF (617 KB) - Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation
SAP couples Fyn to SLAM immune receptors - pp155 - 160
Betty Chan, Arpad Lanyi, Hyun Kyu Song, Jan Griesbach, Maria Simarro-Grande, Florence Poy, Duncan Howie, Janos Sumegi, Cox Terhorst & Michael J. Eck
doi:10.1038/ncb920
First Paragraph - | Full Text - SAP couples Fyn to SLAM immune receptors | PDF (1,095 KB) - SAP couples Fyn to SLAM immune receptors
Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1 - pp161 - 165
Akiko Kumagai & William G. Dunphy
doi:10.1038/ncb921
First Paragraph - | Full Text - Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1 | PDF (1,372 KB) - Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1 | Supplementary information
Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry - pp166 - 170
Roger Albertson & Chris Q. Doe
doi:10.1038/ncb922
First Paragraph - | Full Text - Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry | PDF (2,916 KB) - Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry | Supplementary information
Brief Communication
Native Myosin-IXb is a plus-, not a minus-end-directed motor - pp171 - 172
Christopher B. O'Connell & Mark S. Mooseker
doi:10.1038/ncb924
Abstract - | Full Text - Native Myosin-IXb is a plus-, not a minus-end-directed motor | PDF (279 KB) - Native Myosin-IXb is a plus-, not a minus-end-directed motor | Supplementary information


