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Letter
Nature Cell Biology 5, 137–142 (1 February 2003) | doi:10.1038/ncb923
Direct interaction of two polarity complexes implicated in epithelial tight junction assembly
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Abstract
Tight junctions help establish polarity in mammalian epithelia by forming a physical barrier that separates apical and basolateral membranes. Two evolutionarily conserved multi-protein complexes, Crumbs (Crb)–PALS1 (Stardust)–PATJ (DiscsLost) and Cdc42–Par6–Par3–atypical protein kinase C (aPKC), have been implicated in the assembly of tight junctions and in polarization of Drosophila melanogaster epithelia.
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