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Letter
Nature Cell Biology 5, 166–170 (1 February 2003) | doi:10.1038/ncb922
Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry
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Abstract
Asymmetric cell division is important in generating cell diversity from bacteria to mammals. Drosophila melanogaster neuroblasts are a useful model system for investigating asymmetric cell division because they establish distinct apical–basal cortical domains, have an asymmetric mitotic spindle aligned along the apical–basal axis, and divide unequally to produce a large apical neuroblast and a small basal daughter cell (GMC).
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