Brief Communication abstract
Nature Cell Biology 5, 171 - 172 (2003)
Published online: 31 January 2003 | doi:10.1038/ncb924
Native Myosin-IXb is a plus-, not a minus-end-directed motor
Christopher B. O'Connell1 & Mark S. Mooseker1,2,3
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Top of pageMyosin-IXb (Myo9b) is a single-headed, processive motor1, 2 that contains a Rho-GTPase-activating protein (GAP) domain within its tail3, 4. Although tail-less myosin-IXb motor domain moves towards the minus end of the actin filament2, we show here that full-length myosin-IXb is a plus-end-directed motor. This suggests that the tail domain of myosin-IXb regulates motor directionality.
- Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06511, USA
- Department of Pathology, Yale University School of Medicine, New Haven, CT 06511, USA
- Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
Correspondence to: Mark S. Mooseker1,2,3 e-mail: mark.mooseker@yale.edu
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