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Letter

Nature Cell Biology 5, 1104–1110 (1 December 2003) | doi:10.1038/ncb1071

Rac|[ndash]|MEKK3|[ndash]|MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock

Mark T. Uhlik , Amy N. Abell , Nancy L. Johnson , Weiyong Sun , Bruce D. Cuevas , Katherine E. Lobel-Rice , Eric A. Horne , Mark L. Dell'Acqua & Gary L. Johnson

Sensing the osmolarity of the environment is a critical response for all organisms. Whereas bacteria will migrate away from high osmotic conditions, most eukaryotic cells are not motile and use adaptive metabolic responses for survival.