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Letter

Nature Cell Biology 5, 1083–1089 (1 December 2003) | doi:10.1038/ncb1070

Mitochondrial translocation of cofilin is an early step in apoptosis induction

Boon Tin Chua , Christiane Volbracht , Kuan Onn Tan , Rong Li , Victor C. Yu & Peng Li

Increasing evidence suggests that movement of key proteins in or out of mitochondria during apoptosis is essential for the regulation of apoptosis. Here, we report identification of the actin-binding protein cofilin by a proteomic approach, as such a factor translocated from cytosol into mitochondria after induction of apoptosis.