Nature Cell Biology
5, 1048 - 1049 (2003)
doi:10.1038/ncb1203-1048
Go ahead, break my symmetry!Kendall J. Blumer
& John A. Cooper
Kendall J. Blumer and John A. Cooper are in the Department of Cell Biology, Washington University, St Louis, MO 63110, USA.
kblumer@wustl.edu or jcooper@wustl.edu
Work in this issue advances our understanding of how the small G protein Cdc42 functions to polarize budding yeast. Remarkably, Cdc42 can polarize in the absence of upstream cues or positive feedback from the cytoskeleton. Polarization requires the scaffold protein Bem1 and cycling of Cdc42 between its GTP- and GDP-bound states.
|
