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Nature Cell Biology 5, 1045 - 1047 (2003)
doi:10.1038/ncb1203-1045
AP-1B: polarized sorting at the endosome
Linton M. Traub1 & Gerard Apodaca2
- Linton M. Traub is at the Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA. e-mail: traub@pitt.edu
- Gerard Apodaca is at the Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA.
Abstract
Polarized epithelia require selective protein trafficking to establish and preserve distinct apical and basolateral surfaces. Recent work indicates that in polarized cells, the AP-1B clathrin adaptor recognizes certain basolateral targeting signals in an endosomal compartment where it seems to not only capture cargo but also promote recruitment of targeting and fusion machinery, ensuring accurate polarized sorting.
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