Journal home
Advance online publication
Current issue
Archive
Press releases
Supplements and Focuses
Image gallery
Guide to authors
Online submissionOnline submission
Permissions
For referees
Free online issue
Contact the journal
Subscribe
Advertising
work@npg
naturereprints
About this site
For librarians
 
NPG Resources
Nature
Nature Reviews Molecular Cell Biology
UCSD-Nature Signaling Gateway
The Cell Migration Gateway
Nature Reports Stem Cells
Nature Reports Avian Flu
NPG Subject areas
Biotechnology
Cancer
Chemistry
Clinical Medicine
Dentistry
Development
Drug Discovery
Earth Sciences
Evolution & Ecology
Genetics
Immunology
Materials Science
Medical Research
Microbiology
Molecular Cell Biology
Neuroscience
Pharmacology
Physics
Browse all publications
News and Views
Nature Cell Biology  5, 1045 - 1047 (2003)
doi:10.1038/ncb1203-1045

AP-1B: polarized sorting at the endosome

Linton M. Traub1 & Gerard Apodaca2

1  Linton M. Traub is at the Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA. traub@pitt.edu

2  Gerard Apodaca is at the Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA.

Polarized epithelia require selective protein trafficking to establish and preserve distinct apical and basolateral surfaces. Recent work indicates that in polarized cells, the AP-1B clathrin adaptor recognizes certain basolateral targeting signals in an endosomal compartment where it seems to not only capture cargo but also promote recruitment of targeting and fusion machinery, ensuring accurate polarized sorting.

MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated

REVIEWS
Polarized epithelial membrane traffic: conservation and plasticity
Nature Cell Biology Review (01 Apr 2003)

RESEARCH
The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane
Nature Cell Biology Brief Communication (01 Aug 2002)
AP-4 binds basolateral signals and participates in basolateral sorting in epithelial MDCK cells
Nature Cell Biology Brief Communication (01 Feb 2002)
mu1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors
The EMBO Journal Article (15 May 2000)

 Top
Abstract
Previous | Next
Table of contents
Full textFull text
Download PDFDownload PDF
Send to a friendSend to a friend
Save this linkSave this link

naturejobs

Figures & Tables
Export citation
natureproducts

Search buyers guide:

 
ADVERTISEMENT
 
Nature Cell Biology
ISSN: 1465-7392
EISSN: 1476-4679
Journal home | Advance online publication | Current issue | Archive | Press releases | For authors | Online submission | For referees | Free online issue | About the journal | Contact the journal | Subscribe | Advertising | work@npg | Reprints and permissions | About this site | For librarians
Nature Publishing Group, publisher of Nature, and other science journals and reference works©2003 Nature Publishing Group | Privacy policy