The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?
Dieter A. Wolf, Chunshui Zhou
& Susan Wee
Dieter A. Wolf, Chunshui Zhou and Susan Wee are in the Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
The COP9 signalosome (CSN) is a highly conserved protein complex implicated in diverse biological functions that involve ubiquitin-mediated proteolysis. Paradoxically, conserved enzymatic activities associated with CSN inhibit cullin ubiquitin ligase activity in vitro, whereas mutational analysis suggests that CSN promotes cullin-dependent proteolysis in vivo. This apparent paradox can be resolved in a model that proposes CSN-mediated cullin inhibition is a prerequisite for the proper assembly and maintenance of active cullin ubiquitin ligase complexes.
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