Perspective abstract

Nature Cell Biology 5, 1029 - 1033 (2003)
doi:10.1038/ncb1203-1029

The COP9 signalosome: an assembly and maintenance platform for cullin ubiquitin ligases?

Dieter A. Wolf1, Chunshui Zhou1 & Susan Wee1

The COP9 signalosome (CSN) is a highly conserved protein complex implicated in diverse biological functions that involve ubiquitin-mediated proteolysis. Paradoxically, conserved enzymatic activities associated with CSN inhibit cullin ubiquitin ligase activity in vitro, whereas mutational analysis suggests that CSN promotes cullin-dependent proteolysis in vivo. This apparent paradox can be resolved in a model that proposes CSN-mediated cullin inhibition is a prerequisite for the proper assembly and maintenance of active cullin ubiquitin ligase complexes.

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  1. Dieter A. Wolf, Chunshui Zhou and Susan Wee are in the Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.

Correspondence to: Dieter A. Wolf1 e-mail: dwolf@hsph.harvard.edu



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