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Letter

Nature Cell Biology 5, 972–979 (1 November 2003) | doi:10.1038/ncb1059

Actin filament uncapping localizes to ruffling lamellae and rocketing vesicles

Philip G. Allen

Regulated actin filament assembly is critical for eukaryotic cell physiology. Actin filaments are polar structures, and those with free high affinity or barbed ends are crucial for actin dynamics and cell motility.