NCB demography – democracy? - p937

doi:10.1038/ncb1103-937

Full Text - NCB demography – democracy? | PDF (58 KB) - NCB demography – democracy?

The case for morphogens in plants - pp939 - 943

Rishikesh P. Bhalerao & Malcolm J. Bennett

doi:10.1038/ncb1103-939

Abstract - | Full Text - The case for morphogens in plants | PDF (211 KB) - The case for morphogens in plants

What is lost in translation? - p944

Henry R. Bourne reviews Signal Transduction and Human Disease by Toren Finkel & J. Silvio Gutkind

doi:10.1038/ncb1103-944

Full Text - What is lost in translation? | PDF (85 KB) - What is lost in translation?

The kinetochore NUPtials - pp945 - 947

P. Todd Stukenberg & Ian G. Macara

doi:10.1038/ncb1103-945

The most interesting discoveries are often those that couple distinct fields of science in unexpected ways. The marriage of the nuclear pore complex to the kinetochore and spindle checkpoint regulation is a recent example, raising the question of why such divergent processes as mitosis and nuclear transport use common proteins.

Full Text - The kinetochore NUPtials | PDF (157 KB) - The kinetochore NUPtials

Architects of the chromosome - p947

Donald McDonald

doi:10.1038/ncb1103-947

Full Text - Architects of the chromosome | PDF (101 KB) - Architects of the chromosome

Stuck without Traffic Jam - pp948 - 949

Helen McNeill

doi:10.1038/ncb1103-948

During organogenesis different cells must recognize and adhere to each other in a complicated orchestration of cell movements that requires intricate regulation of cell adhesions. A Maf transcription factor, Traffic jam, has been found to regulate a panel of cell adhesion molecules, and the interactions between germ cells and somatic cells to shape the mature gonad.

Full Text - Stuck without Traffic Jam | PDF (129 KB) - Stuck without Traffic Jam

BTB proteins as henchmen of Cul3-based ubiquitin ligases - pp950 - 951

Wilhelm Krek

doi:10.1038/ncb1103-950

The choice of ubiquitination substrates of Cul1- and Cul2-based E3 ubiquitin protein ligase complexes is dictated by the identity of their substrate-specific adaptors, known as F-box and BC-box proteins, respectively. Recent work suggests that members of the large family of BTB-domain proteins define a new class of substrate-specific adaptors of Cul3-based E3 complexes. This finding places many signalling pathways in which BTB-domain proteins participate under direct control of the ubiquitination pathway.

Full Text - BTB proteins as henchmen of Cul3-based ubiquitin ligases | PDF (121 KB) - BTB proteins as henchmen of Cul3-based ubiquitin ligases

Stem cell fusion in the brain - pp952 - 954

Yevgenia Kozorovitskiy & Elizabeth Gould

doi:10.1038/ncb1103-952

Bone-marrow-derived stem cells have been shown to contribute to Purkinje neurons in the cerebellum of adult humans and mice. A new study identifies cell fusion as the mechanism underlying this phenomenon, and shows that the bone marrow cell portion of the resulting binucleate heterokaryons acquires the morphological and molecular characteristics of Purkinje neurons over time.

Full Text - Stem cell fusion in the brain | PDF (164 KB) - Stem cell fusion in the brain

Plant microtubule nucleation sites: moving right along - p954

Sue Wick

doi:10.1038/ncb1103-954

Full Text - Plant microtubule nucleation sites: moving right along | PDF (102 KB) - Plant microtubule nucleation sites: moving right along

Three Yips for Rab recruitment - pp955 - 956

Jemima Barrowman & Peter Novick

doi:10.1038/ncb1103-955

Rab GTPases function at all stages of the endocytic and exocytic pathways. Although it is clear that each Rab is required for specific transport events, the process by which they are recruited to distinct compartments along the membrane trafficking pathway has remained obscure. Recent data suggests that a member of the Yip family is important for the membrane recruitment of endosomal Rabs.

Full Text - Three Yips for Rab recruitment | PDF (112 KB) - Three Yips for Rab recruitment

Cell of the month: An insect blood cell engulfing bacteria - p957

Paul Dean

doi:10.1038/ncb1103-957

Full Text - Cell of the month: An insect blood cell engulfing bacteria | PDF (212 KB) - Cell of the month: An insect blood cell engulfing bacteria

Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant - pp959 - 966

James M. Weimann, Clas B. Johansson, Angelica Trejo & Helen M. Blau

doi:10.1038/ncb1053

Abstract - | Full Text - Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant | PDF (1,371 KB) - Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant

See also: News and Views by Kozorovitskiy & Gould

EB1 reveals mobile microtubule nucleation sites in Arabidopsis - pp967 - 971

Jordi Chan, Grant M. Calder, John H. Doonan & Clive W. Lloyd

doi:10.1038/ncb1057

First Paragraph - | Full Text - EB1 reveals mobile microtubule nucleation sites in Arabidopsis | PDF (605 KB) - EB1 reveals mobile microtubule nucleation sites in Arabidopsis | Supplementary information

See also: News and Views by Wick

Actin filament uncapping localizes to ruffling lamellae and rocketing vesicles - pp972 - 979

Philip G. Allen

doi:10.1038/ncb1059

First Paragraph - | Full Text - Actin filament uncapping localizes to ruffling lamellae and rocketing vesicles | PDF (1,991 KB) - Actin filament uncapping localizes to ruffling lamellae and rocketing vesicles | Supplementary information

Load-dependent kinetics of force production by smooth muscle myosin measured with optical tweezers - pp980 - 986

Claudia Veigel, Justin E. Molloy, Stephan Schmitz & John Kendrick-Jones

doi:10.1038/ncb1060

First Paragraph - | Full Text - Load-dependent kinetics of force production by smooth muscle myosin measured with optical tweezers | PDF (438 KB) - Load-dependent kinetics of force production by smooth muscle myosin measured with optical tweezers

Discs-Large and Strabismus are functionally linked to plasma membrane formation - pp987 - 993

Ok-Kyung Lee, Kristopher K. Frese, Jennifer S. James, Darshana Chadda, Zhi-Hong Chen, Ronald T. Javier & Kyung-Ok Cho

doi:10.1038/ncb1055

First Paragraph - | Full Text - Discs-Large and Strabismus are functionally linked to plasma membrane formation | PDF (2,472 KB) - Discs-Large and Strabismus are functionally linked to plasma membrane formation | Supplementary information

The large Maf factor Traffic Jam controls gonad morphogenesis in Drosophila - pp994 - 1000

Michelle A. Li, Jeffrey D. Alls, Rita M. Avancini, Karen Koo & Dorothea Godt

doi:10.1038/ncb1058

First Paragraph - | Full Text - The large Maf factor Traffic Jam controls gonad morphogenesis in Drosophila | PDF (1,973 KB) - The large Maf factor Traffic Jam controls gonad morphogenesis in Drosophila | Supplementary information

See also: News and Views by McNeill

Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases - pp1001 - 1007

Manabu Furukawa, Yizhou Joseph He, Christoph Borchers & Yue Xiong

doi:10.1038/ncb1056

First Paragraph - | Full Text - Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases | PDF (354 KB) - Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases | Supplementary information

See also: News and Views by Krek

Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint - pp1008 - 1015

Leigh Ann A. Higa, Ivailo S. Mihaylov, Damon P. Banks, Jianyu Zheng & Hui Zhang

doi:10.1038/ncb1061

First Paragraph - | Full Text - Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint | PDF (550 KB) - Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint | Supplementary information

Production of PtdInsP₃ at endomembranes is triggered by receptor endocytosis - pp1016 - 1022

Moritoshi Sato, Yoshibumi Ueda, Tokio Takagi & Yoshio Umezawa

doi:10.1038/ncb1054

First Paragraph - | Full Text - Production of PtdInsP3 at endomembranes is triggered by receptor endocytosis | PDF (459 KB) - Production of PtdInsP3 at endomembranes is triggered by receptor endocytosis

Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1 - pp1023 - 1025

Mary Herbert, Mark Levasseur, Hayden Homer, Katie Yallop, Alison Murdoch & Alex McDougall

doi:10.1038/ncb1062

Abstract - | Full Text - Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1 | PDF (288 KB) - Homologue disjunction in mouse oocytes requires proteolysis of securin and cyclin B1 | Supplementary information