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Letter
Nature Cell Biology 5, 1008–1015 (1 November 2003) | doi:10.1038/ncb1061
Radiation-mediated proteolysis of CDT1 by CUL4|[ndash]|ROC1 and CSN complexes constitutes a new checkpoint
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Abstract
Genomic integrity is maintained by checkpoints that guard against undesired replication after DNA damage. Here, we show that CDT1, a licensing factor of the pre-replication complex (preRC), is rapidly proteolysed after UV- or γ-irradiation.
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