News and Views

Nature Cell Biology 5, 950 - 951 (2003)
doi:10.1038/ncb1103-950

BTB proteins as henchmen of Cul3-based ubiquitin ligases

Wilhelm Krek1

  1. Wilhelm Krek is in the Institute of Cell Biology, ETH-Hönggerberg, CH-8093 Zurich, Switzerland. e-mail: wilhelm.krek@cell.biol.ethz.ch

The choice of ubiquitination substrates of Cul1- and Cul2-based E3 ubiquitin protein ligase complexes is dictated by the identity of their substrate-specific adaptors, known as F-box and BC-box proteins, respectively. Recent work suggests that members of the large family of BTB-domain proteins define a new class of substrate-specific adaptors of Cul3-based E3 complexes. This finding places many signalling pathways in which BTB-domain proteins participate under direct control of the ubiquitination pathway.

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