Lasker goes transcriptional - p841

doi:10.1038/ncb1003-841

Full Text - Lasker goes transcriptional | PDF (109 KB) - Lasker goes transcriptional

In the path of art and science: Dresden's red pill - p843

A. Ruiz i Altaba reviews Gentle Bridges: Architecture, Art and Science by R. Anthony Hyman, Gerhard Mack, Juhani Pallasmaa & Marino Zerial

doi:10.1038/ncb1003-843

Full Text - In the path of art and science: Dresden's red pill | PDF (92 KB) - In the path of art and science: Dresden's red pill

Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation - pp845 - 850

J. Russell Lipford & Raymond J. Deshaies

doi:10.1038/ncb1003-845

Abstract - Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation | Full Text - Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation | PDF (190 KB) - Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation

How attraction turns to repulsion - pp851 - 853

David G. Wilkinson

doi:10.1038/ncb1003-851

During cell-contact-mediated repulsion, an initially adhesive interaction between a receptor and its ligand ultimately results in a repulsive response that causes the cells to separate. Two studies looking at the case of Eph receptors and ephrins now identify a crucial role for endocytosis in this enigmatic process.

Full Text - How attraction turns to repulsion | PDF (147 KB) - How attraction turns to repulsion

Hippo and its mission for growth control - pp853 - 855

Hyung Don Ryoo & Hermann Steller

doi:10.1038/ncb1003-853

During development, tissue growth is controlled by coordinated cellular growth and apoptosis. A series of recent papers describes a newly identified Drosophila gene, hippo, that restricts excessive growth during development by both limiting cell cycle progression and promoting susceptibility to apoptosis. Therefore, hippo may coordinate the regulation of cell division and cell death.

Full Text - Hippo and its mission for growth control | PDF (182 KB) - Hippo and its mission for growth control

From shoot to root - p855

Alison Schuldt

doi:10.1038/ncb1003-855

Full Text - From shoot to root | PDF (133 KB) - From shoot to root

Cdc34: cycling on and off the SCF - pp856 - 857

Lionel Pintard & Matthias Peter

doi:10.1038/ncb1003-856

Polyubiquitination of substrates requires the coordinated and sequential action of three enzymes: E1, E2 and E3. Now, a study shows that activated E2 associates transiently with E3, and that subsequent release of the E2 is functionally required for substrate polyubiquitination.

Full Text - Cdc34: cycling on and off the SCF | PDF (116 KB) - Cdc34: cycling on and off the SCF

Of fertility, cystic fibrosis and the bicarbonate ion - pp857 - 859

Keith A. Sutton, Melissa K. Jungnickel & Harvey M. Florman

doi:10.1038/ncb1003-857

Mammalian sperm require activation within the female reproductive tract to fertilize eggs, and bicarbonate is essential for this process in vitro. A recent study implicates the cystic fibrosis transmembrane regulator (CFTR) as a possible regulator for bicarbonate release in vivo.

Full Text - Of fertility, cystic fibrosis and the bicarbonate ion | PDF (137 KB) - Of fertility, cystic fibrosis and the bicarbonate ion

Timing the cell cycle - pp859 - 861

Luca Cardone & Paolo Sassone-Corsi

doi:10.1038/ncb1003-859

Most cells contain two endogenous clocks, one devoted to the control of cell division and the other acting as circadian pacemaker. Although classically thought to be independent, recent findings challenge this view, as molecular components of the circadian clock directly regulate WEE1, a kinase that inhibits mitosis by inactivating Cdc2/cyclin B.

Full Text - Timing the cell cycle | PDF (138 KB) - Timing the cell cycle

Wnt signalling gets XEEKy - pp861 - 863

Wilson K. Clements & David Kimelman

doi:10.1038/ncb1003-861

The putative tumour suppressor LKB1/XEEK1 (Xenopus egg and embryo kinase 1) has been implicated in many cellular processes and signalling pathways. Now, XEEK1 is found to exist in a complex with GSK3 (glycogen synthase kinase 3) and protein kinase C (PKC), resulting in increased Wnt signal transduction during embryonic development. This discovery positions XEEK1 as a potential intersection point for crosstalk between Wnt and other pathways.

Full Text - Wnt signalling gets XEEKy | PDF (208 KB) - Wnt signalling gets XEEKy

Can Fizzy fly solo? - pp864 - 865

Peter K. Jackson

doi:10.1038/ncb1003-864

To ensure genome stability, the S-phase checkpoint blocks spindle elongation during S phase. Later, the spindle assembly checkpoint blocks chromosome segregation by restraining CDC20/Fizzy-dependent activation of the anaphase-promoting complex (APC). Now, a study suggests that the S-phase checkpoint also limits accumulation of Cdc20p and, unexpectedly, an APC-independent CDC20 function for spindle elongation.

Full Text - Can Fizzy fly solo? | PDF (112 KB) - Can Fizzy fly solo?

Cell of the month: Human Langerhans cell in a dermal lymphatic vessel - p867

Kristian Pfaller

doi:10.1038/ncb1003-867

Full Text - Cell of the month: Human Langerhans cell in a dermal lymphatic vessel | PDF (350 KB) - Cell of the month: Human Langerhans cell in a dermal lymphatic vessel

Rac-dependent trans-endocytosis of ephrinBs regulates Eph–ephrin contact repulsion - pp879 - 888

Daniel J. Marston, Sarah Dickinson & Catherine D. Nobes

doi:10.1038/ncb1044

Abstract - Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion | Full Text - Rac-dependent trans-endocytosis of ephrinBs regulates Eph–ephrin contact repulsion | PDF (3,098 KB) - Rac-dependent trans-endocytosis of ephrinBs regulates Eph–ephrin contact repulsion | Supplementary information

EphB–ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion - pp869 - 878

Manuel Zimmer, Amparo Palmer, Jenny Köhler & Rüdiger Klein

doi:10.1038/ncb1045

Abstract - EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion | Full Text - EphB–ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion | PDF (2,634 KB) - EphB–ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion | Supplementary information

S-phase checkpoint controls mitosis via an APC-independent Cdc20p function - pp928 - 935

Duncan J. Clarke, Marisa Segal, Catherine A. Andrews, Stanislav G. Rudyak, Sanne Jensen, Karen Smith & Steven I. Reed

doi:10.1038/ncb1046

First Paragraph - S-phase checkpoint controls mitosis via an APC-independent Cdc20p function | Full Text - S-phase checkpoint controls mitosis via an APC-independent Cdc20p function | PDF (544 KB) - S-phase checkpoint controls mitosis via an APC-independent Cdc20p function | Supplementary information

See also: News and Views by Jackson

Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm - pp902 - 906

Xiao Fei Wang, Chen Xi Zhou, Qi Xian Shi, Yu Ying Yuan, Mei Kuen Yu, Louis Chukwuemeka Ajonuma, Lok Sze Ho, Pui Shan Lo, Lai Ling Tsang, Yu Liu, Sun Yi Lam, Ling Nga Chan, Wen Chao Zhao, Yiu Wa Chung & Hsiao Chang Chan

doi:10.1038/ncb1047

First Paragraph - Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm | Full Text - Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm | PDF (297 KB) - Involvement of CFTR in uterine bicarbonate secretion and the fertilizing capacity of sperm

See also: News and Views by Sutton et al.

LKB1 (XEEK1) regulates Wnt signalling in vertebrate development - pp889 - 894

Olga Ossipova, Nabeel Bardeesy, Ronald A. DePinho & Jeremy B. A. Green

doi:10.1038/ncb1048

First Paragraph - LKB1 (XEEK1) regulates Wnt signalling in vertebrate development | Full Text - LKB1 (XEEK1) regulates Wnt signalling in vertebrate development | PDF (757 KB) - LKB1 (XEEK1) regulates Wnt signalling in vertebrate development | Supplementary information

See also: News and Views by Clements & Kimelman

Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein - pp895 - 901

Anna Jawiska, Carlos Ribeiro & Markus Affolter

doi:10.1038/ncb1049

First Paragraph - Epithelial tube morphogenesis during : Drosophila: tracheal development requires Piopio, a luminal ZP protein | Full Text - Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein | PDF (1,449 KB) - Epithelial tube morphogenesis during Drosophila tracheal development requires Piopio, a luminal ZP protein | Supplementary information

Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway - pp914 - 920

Ryan S. Udan, Madhuri Kango-Singh, Riitta Nolo, Chunyao Tao & Georg Halder

doi:10.1038/ncb1050

First Paragraph - Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway | Full Text - Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway | PDF (1,244 KB) - Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway | Supplementary information

See also: News and Views by Ryoo & Steller

The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila - pp921 - 927

Sophie Pantalacci, Nicolas Tapon & Pierre Léopold

doi:10.1038/ncb1051

First Paragraph - The Salvador partner Hippo promotes apoptosis and cell-cycle exit in : Drosophila | Full Text - The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila | PDF (1,927 KB) - The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila | Supplementary information

See also: News and Views by Ryoo & Steller

Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog - pp907 - 913

Laurent Ruel, Ralph Rodriguez, Armel Gallet, Laurence Lavenant-Staccini & Pascal P. Thérond

doi:10.1038/ncb1052

Abstract - Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog | Full Text - Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog | PDF (2,192 KB) - Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog | Supplementary information